interleukin 1 alpha
Ultimo aggiornamento 23 Mar 2022
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L IL1A gene provides instructions for making a protein called interleukin-1 alpha. Interleukins are a group of proteins that are made primarily in immune system cells. They are involved in cell-to-cell communication and have a wide variety of functions within the immune system. Interleukin-1 alpha is described as "pro-inflammatory" because it stimulates the activity of genes involved in inflammation and immunity. This protein plays a critical role in protecting the body from foreign invaders such as bacteria and viruses. It is also involved in bone resorption, the breakdown and removal of bone tissue that is no longer needed.
Normal function
L IL1A gene provides instructions for making a protein called interleukin-1 alpha. Interleukins are a group of proteins that are made primarily in immune system cells. They are involved in cell-to-cell communication and have a wide variety of functions within the immune system. Interleukin-1 alpha is described as "pro-inflammatory" because it stimulates the activity of genes involved in inflammation and immunity. This protein plays a critical role in protecting the body from foreign invaders such as bacteria and viruses. It is also involved in bone resorption, the breakdown and removal of bone tissue that is no longer needed.
Interleukin-1 alpha is initially produced as a relatively long protein that is trapped within cells. Another protein, called calpain, cuts (cleaves) this precursor protein to create a shorter, mature version of interleukin-1 alpha. The shorter form of this protein is secreted by immune system cells to influence the functions of other cells.
Conditions referring to this gene or chromosome
Altri nomi
hematopoietin-1
IL-1 alpha
IL-1A
IL1
IL1-ALPHA
IL1A_HUMAN
IL1F1
interleukin 1, alpha
Interleukin-1 alpha
preinterleukin 1 alpha
pro-interleukin-1-alpha
Related patient information and medicines
Patient information leaflet
Cancro del rene
In the UK, over 12,500 people are diagnosed with kidney cancer each year. Radiotherapy was previously rarely used for renal cell carcinoma but newer methods have enabled the delivery of radiation treatment dire... Immunotherapy (sometimes called biological therapy) and targeted molecular therapies Immunotherapy using interferon e aldesleukin.
Patient information leaflet
Cancro alla bocca
Immunotherapy is treatment that aims to boost the body's own immune system to destroy the cancer cells. It is also sometimes called biological therapy: Recombinant interleukin (rIL-2) is a form of immunotherapy. It is not known yet whether being treated with a targeted therapy or immunotherapy improves the outcome for people with mouth cancer. How.
Patient information leaflet
Posso prendere Rivaroxaban e Tamsulosina insieme?
However, both medicines can occasionally cause dizziness or lightheadedness,... Taking them together might slightly increase the chance of feeling faint. Why this happens Rivaroxaban è an anticoagulant (blood thinner) and tamsulosin is an alpha-blocker used for prostate symptoms. They are processed by different pathways in the liver and do not.
Patient information leaflet
Posso prendere Lansoprazolo e Tamsulosina insieme?
There are no known significant interactions between... It is generally considered safe to take these two medicines together. Why this happens Lansoprazolo is a proton pump inhibitor (PPI) used to reduce stomach acid, and tamsulosin è an alpha-blocker used to help with urinary symptoms. They are processed by different pathways in the liver and do.
Patient information leaflet
Artrite psoriasica
Surgery is sometimes needed if a joint or tendon becomes badly damaged. What is psoriatic arthritis. Artrite psoriasica è a particular type of arthritis that develops in some people who also have psoriasi. Arthritis means inflammation of the joints. Psoriasis is a common skin condition which typically causes patches (plaques) of red, scaly skin.
Patient information leaflet
Medicinali biologici per l'artrite reumatoide
Biological medicines are a newer type of medicine, used to ease the symptoms of artrite reumatoide and reduce the damaging effect of the disease on the joints. They are usually prescribed when you have tried older medicines called disease-modifying antirheumatic drugs (DMARDs) and these have not worked so well. If a biological medicine is going.
Ulteriori letture e riferimenti
- interleukin 1 alpha; MedlinePlus, National Library of Medicine.
- Asensi V, Alvarez V, Valle E, Meana A, Fierer J, Coto E, Carton JA, Maradona JA, Paz J, Dieguez MA, de la Fuente B, Moreno A, Rubio S, Tuya MJ, Sarasua J, Llames S, Arribas JM. IL-1 alpha (-889) promoter polymorphism is a risk factor for osteomyelitis. Am J Med Genet A. 2003 Jun 1;119A(2):132-6. doi: 10.1002/ajmg.a.20137.
- Brown MA, Xu H, Li Z. Genetics and the axial spondyloarthritis spectrum. Rheumatology (Oxford). 2020 Oct 1;59(Suppl4):iv58-iv66. doi: 10.1093/rheumatology/keaa464.
- Graves DT, Cochran D. The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction. J Periodontol. 2003 Mar;74(3):391-401. doi: 10.1902/jop.2003.74.3.391.
- Kawaguchi Y, Tochimoto A, Hara M, Kawamoto M, Sugiura T, Saito S, Kamatani N. Contribution of single nucleotide polymorphisms of the IL1A gene to the cleavage of precursor IL-1alpha and its transcription activity. Immunogenetics. 2007 Jun;59(6):441-8. doi: 10.1007/s00251-007-0213-y. Epub 2007 Apr 18.
- Lee S, Temple S, Roberts S, Price P. Complex effects of IL1A polymorphism and calpain inhibitors on interleukin 1 alpha (IL-1 alpha) mRNA levels and secretion of IL-1 alpha protein. Tissue Antigens. 2008 Jul;72(1):67-71. doi: 10.1111/j.1399-0039.2008.01052.x. Epub 2008 May 20.
- Sims AM, Timms AE, Bruges-Armas J, Burgos-Vargas R, Chou CT, Doan T, Dowling A, Fialho RN, Gergely P, Gladman DD, Inman R, Kauppi M, Kaarela K, Laiho K, Maksymowych W, Pointon JJ, Rahman P, Reveille JD, Sorrentino R, Tuomilehto J, Vargas-Alarcon G, Wordsworth BP, Xu H, Brown MA; International Genetics of Ankylosing Spondylitis. Prospective meta-analysis of interleukin 1 gene complex polymorphisms confirms associations with ankylosing spondylitis. Ann Rheum Dis. 2008 Sep;67(9):1305-9. doi: 10.1136/ard.2007.081364. Epub 2007 Dec 6.
- Tsezou A, Poultsides L, Kostopoulou F, Zintzaras E, Satra M, Kitsiou-Tzeli S, Malizos KN. Influence of interleukin 1alpha (IL-1alpha), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis. Clin Vaccine Immunol. 2008 Dec;15(12):1888-90. doi: 10.1128/CVI.00209-08. Epub 2008 Oct 29.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.