chloride voltage-gated channel 2
Ultimo aggiornamento 18 Ago 2020
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L CLCN2 gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some chloride channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
Normal function
L CLCN2 gene belongs to the CLC family of genes, which provide instructions for making chloride channels. These channels, which transport negatively charged chlorine atoms (chloride ions), play a key role in a cell's ability to generate and transmit electrical signals. Some chloride channels regulate the flow of chloride ions across cell membranes, while others transport chloride ions within cells.
L CLCN2 gene provides instructions for making a chloride channel called ClC-2. These channels are embedded within the outer membrane of most cells, and they transport chloride ions in and out of cells. The channel's function is thought to be particularly important in nerve cells (neurons) in the brain. The ClC-2 channel regulates the size (volume) of neurons by playing a role in the intake and release of water as well as maintaining a normal balance of ions in cells.
Conditions referring to this gene or chromosome
Altri nomi
chloride channel 2
chloride channel, voltage-sensitive 2
CIC-2
clC-2
CLC2
ECA2
ECA3
EGI11
EGI3
EGMA
EJM6
EJM8
LKPAT
Related patient information and medicines
Patient information leaflet
Fibrosi cistica
Cystic fibrosis is an inherited disease which mainly affects dello lungs and pancreas but can involve other organs. Symptoms usually begin in early childhood and include persistent cough, wheeze, repeated chest infections, difficulty digesting food and general ill health. Treatments include antibiotics, physiotherapy, medicines for thinning mucus,.
Patient information leaflet
Cancro del rene
This is sometimes called renal adenocarcinoma or renal cell carcinoma or hypernephroma. Renal cell cancer This type of cancer develops from a cell in a kidney tubule, which becomes cancerous (malignant). The cancer grows and forms into a tumour within the kidney. As the tumour grows: The affected kidney tends to become larger. In time the tumour.
Patient information leaflet
Ustioni e scottature
Burns caused b... For electrical burns - disconnect the victim from the source of electricity before attempting first aid. If you cannot switch off the electricity: If the person has been injured by a low-voltage source (220-240 volts, domestic electricity supply) poi remove the person from the electrical source, using a non-conductive material.
Patient information leaflet
Piedi sudati
It may lead to smelly feet, and nobody likes stinky feet. This leaflet explains why feet sweat (which is normal) and how to stop your feet from being sweaty or smelly. Why do feet sweat. Sweating is normal. It has three main functions: Heat regulation - sweating cools the body by wetting the surface of the skin. Excretion - another way for the.
Patient information leaflet
Sinusite acuta
Chronic sinusitis This means that an episode of sinusitis becomes persistent and lasts longer than 12 weeks. Chronic sinusitis is common affecting 1 in 10 adults in the UK. See the separate leaflet called Chronic sinusitis for more details. The rest of this leaflet is about acute sinusitis. Acute sinusitis symptoms Common symptoms of sinusitis.
Patient information leaflet
Polipi nasali
Side-effects of topical steroid medications These include nasal irritation, sore throat and nosebleeds. About 1 in 10 people using these medications will experience one of these symptoms. Some people are sensitive to a preservative called benzalkonium chloride, found in all all nasal steroid treatments (drops and sprays), except for Flixonase.
Ulteriori letture e riferimenti
- chloride voltage-gated channel 2; MedlinePlus, National Library of Medicine.
- Gaitan-Penas H, Apaja PM, Arnedo T, Castellanos A, Elorza-Vidal X, Soto D, Gasull X, Lukacs GL, Estevez R. Leukoencephalopathy-causing CLCN2 mutations are associated with impaired Cl- channel function and trafficking. J Physiol. 2017 Nov 15;595(22):6993-7008. doi: 10.1113/JP275087. Epub 2017 Oct 9.
- Stolting G, Fischer M, Fahlke C. CLC channel function and dysfunction in health and disease. Front Physiol. 2014 Oct 7;5:378. doi: 10.3389/fphys.2014.00378. eCollection 2014.
- Wang H, Xu M, Kong Q, Sun P, Yan F, Tian W, Wang X. Research and progress on ClC‑2 (Review). Mol Med Rep. 2017 Jul;16(1):11-22. doi: 10.3892/mmr.2017.6600. Epub 2017 May 18.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.