Can I take Sildenafil and Grapefruit together?

Perché succede

Your body uses a specific enzyme (called CYP3A4) in the gut and liver to break down sildenafil. Grapefruit contains natural compounds that 'block' this enzyme. Because the enzyme is busy dealing with the grapefruit, it cannot break down the sildenafil as quickly as usual, leading to higher-than-intended levels of the drug in your body.

It is best to avoid grapefruit and grapefruit juice entirely while using sildenafil. If you have already consumed grapefruit, wait at least 24 hours before taking a dose of sildenafil. If you experience chest pain, dizziness, or a prolonged erection (lasting more than 4 hours) after taking this combination, seek medical help immediately.

Nitrate medication use (e.g. GTN spray, isosorbide mononitrate)

You must never take sildenafil if you are using nitrate medicines for chest pain or heart problems. Combining them can cause a sudden, life-threatening drop in blood pressure.

Grapefruit consumption

Avoid eating grapefruit or drinking grapefruit juice while using sildenafil. Grapefruit increases the amount of the medicine in your blood, which significantly raises the risk of dangerous side effects.

Pompelmo e succo di pompelmo

Grapefruit juice can increase the amount of sildenafil in your blood. This may increase the risk of side effects like headaches, flushing, or low blood pressure. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcol

Drinking alcohol can make it harder to get an erection. Alcohol can also lower your blood pressure; taking it with sildenafil may cause your blood pressure to drop too low, leading to dizziness or fainting. It is recommended to keep alcohol intake to a minimum.

High-fat meals

If you take sildenafil with a heavy or high-fat meal (such as a burger and chips), the medicine may take longer to start working. For the fastest effect, it is best taken on an empty stomach or with a light meal.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.