Posso prendere Metformina e Sertralina insieme?

Perché succede

Sertraline belongs to a group of medicines called SSRIs, which can change how the body handles glucose and may increase the body's sensitivity to insulin. While the exact way they interact with metformin isn't fully understood, it is known that starting or stopping an antidepressant can cause fluctuations in blood sugar control.

You should monitor your blood sugar levels more frequently when starting sertraline or changing your dose. Be aware of the signs of a 'hypo' (low blood sugar), such as feeling shaky, sweaty, hungry, or dizzy. If you notice significant changes in your blood sugar readings, contact your GP or diabetes specialist, as they may need to adjust your metformin dose.

Disturbi depressivi e d'ansia

You may experience an increase in suicidal thoughts or the urge to self-harm when first starting sertraline or changing the dose. This is more common in young adults under 25. Contact your doctor or go to hospital immediately if you notice any changes in your mood or behaviour.

Acidosi lattica

Metformin can cause a rare but serious build-up of acid in the blood. Seek urgent medical help if you experience extreme tiredness, muscle pain, or difficulty breathing. This risk is higher if you have severe kidney problems or drink excessive alcohol.

Disturbi emorragici

Sertraline can increase your risk of bleeding, particularly from the stomach. Use with caution if you take blood-thinning medicines (like warfarin) or anti-inflammatory painkillers (like ibuprofen or aspirin), as this significantly increases the risk of serious bleeding.

Sindrome serotoninergica

Sertraline can cause a life-threatening condition called serotonin syndrome, especially if taken with other medicines that affect serotonin (such as triptans, tramadol, or St John's Wort). Seek urgent medical help if you experience agitation, hallucinations, fast heartbeat, or severe muscle stiffness.

Severe dehydration or infection

If you develop severe vomiting, diarrhoea, or a high fever, you must temporarily stop taking metformin and contact your doctor to prevent kidney strain.

Medical scans using iodine contrast dye

If you are having an X-ray or scan involving an injection of iodine contrast dye, you must stop taking metformin before or at the time of the test to prevent sudden kidney failure.

Alcol

It is best to avoid or strictly limit alcohol while taking metformin. Drinking alcohol with this medicine increases the risk of a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood). It also increases the risk of low blood sugar (hypoglycaemia).

È meglio evitare o limitare strettamente l'alcol durante l'assunzione di sertralina. Combinare l'alcol con questo medicinale può aumentare gli effetti collaterali come sonnolenza, vertigini e coordinazione compromessa. Può anche peggiorare i sintomi della depressione o dell'ansia.

Succo di pompelmo

Evita di bere grandi quantità di succo di pompelmo. Il pompelmo contiene composti che possono aumentare i livelli di sertralina nel sangue, il che potrebbe aumentare il rischio di effetti collaterali.

Caffeina (Caffè, Tè, Bevande Energetiche)

Be cautious with caffeine intake. Sertraline can sometimes make you feel jittery or anxious, and caffeine can worsen these sensations. Additionally, some studies suggest sertraline may slightly increase caffeine levels in the body.

Vitamin B12 absorption

Long-term use of metformin can prevent your body from absorbing enough vitamin B12 from your food. You may need to have your B12 levels checked by your doctor or take a supplement if you develop symptoms like extreme tiredness or a sore tongue.

General Food Advice

Metformin should be taken with or just after a meal or snack. This helps to reduce the risk of common side effects such as stomach upset, indigestion, or nausea.

Assumi più farmaci? Il nostro Controllo Interazioni Farmaci ti aiuta a verificare se le tue prescrizioni, i farmaci da banco e gli integratori sono sicuri da assumere insieme. Basta cercare i tuoi farmaci per vedere le potenziali interazioni e cosa fare al riguardo.

Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.