Posso prendere Metformina e Sertralina insieme?

Perché succede

Sertraline belongs to a group of medicines called SSRIs, which can change how the body handles glucose and may increase the body's sensitivity to insulin. While the exact way they interact with metformin isn't fully understood, it is known that starting or stopping an antidepressant can cause fluctuations in blood sugar control.

You should monitor your blood sugar levels more frequently when starting sertraline or changing your dose. Be aware of the signs of a 'hypo' (low blood sugar), such as feeling shaky, sweaty, hungry, or dizzy. If you notice significant changes in your blood sugar readings, contact your GP or diabetes specialist, as they may need to adjust your metformin dose.

Disturbi depressivi e d'ansia

Potresti sperimentare un aumento dei pensieri suicidi o dell'impulso di autolesionarti all'inizio del trattamento con sertralina o quando cambi la dose. Questo è più comune nei giovani adulti sotto i 25 anni. Contatta immediatamente il tuo medico o vai in ospedale se noti cambiamenti nel tuo umore o nel tuo comportamento.

Acidosi lattica

Metformin can cause a rare but serious build-up of acid in the blood. Seek urgent medical help if you experience extreme tiredness, muscle pain, or difficulty breathing. This risk is higher if you have severe kidney problems or drink excessive alcohol.

Disturbi emorragici

Sertraline can increase your risk of bleeding, particularly from the stomach. Use with caution if you take blood-thinning medicines (like warfarin) or anti-inflammatory painkillers (like ibuprofen or aspirin), as this significantly increases the risk of serious bleeding.

Sindrome serotoninergica

Sertraline can cause a life-threatening condition called serotonin syndrome, especially if taken with other medicines that affect serotonin (such as triptans, tramadol, or St John's Wort). Seek urgent medical help if you experience agitation, hallucinations, fast heartbeat, or severe muscle stiffness.

Severe dehydration or infection

If you develop severe vomiting, diarrhoea, or a high fever, you must temporarily stop taking metformin and contact your doctor to prevent kidney strain.

Medical scans using iodine contrast dye

If you are having an X-ray or scan involving an injection of iodine contrast dye, you must stop taking metformin before or at the time of the test to prevent sudden kidney failure.

Alcol

It is best to avoid or strictly limit alcohol while taking metformin. Drinking alcohol with this medicine increases the risk of a rare but serious condition called lactic acidosis (a build-up of lactic acid in the blood). It also increases the risk of low blood sugar (hypoglycaemia).

It is best to avoid or strictly limit alcohol while taking sertraline. Combining alcohol with this medicine can increase side effects such as drowsiness, dizziness, and impaired coordination. It may also make your depression or anxiety symptoms worse.

Succo di pompelmo

Evita di bere grandi quantità di succo di pompelmo. Il pompelmo contiene composti che possono aumentare i livelli di sertralina nel sangue, il che potrebbe aumentare il rischio di effetti collaterali.

Caffeina (Caffè, Tè, Bevande Energetiche)

Be cautious with caffeine intake. Sertraline can sometimes make you feel jittery or anxious, and caffeine can worsen these sensations. Additionally, some studies suggest sertraline may slightly increase caffeine levels in the body.

Vitamin B12 absorption

Long-term use of metformin can prevent your body from absorbing enough vitamin B12 from your food. You may need to have your B12 levels checked by your doctor or take a supplement if you develop symptoms like extreme tiredness or a sore tongue.

General Food Advice

Metformin should be taken with or just after a meal or snack. This helps to reduce the risk of common side effects such as stomach upset, indigestion, or nausea.

Taking multiple medicines? Our Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.