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Can I take Magnesium and St John's wort together?

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There are no known significant interactions between magnesium supplements and St John's Wort. It is generally considered safe to take these two together.

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Perché succede

Magnesium and St John's Wort are processed by the body through different pathways. Magnesium is a mineral primarily regulated by the kidneys, while St John's Wort affects liver enzymes (specifically CYP3A4). They do not interfere with each other's absorption or effectiveness.

You can take these together. However, always inform your doctor or pharmacist about all supplements you are taking, as St John's Wort interacts with many prescription medicines (such as antidepressants, blood thinners, and the contraceptive pill).

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Depression and Mental Health

Like other antidepressants, St John's wort may increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment. Seek immediate medical help if your mood worsens.

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St John's wort significantly reduces the effectiveness of many essential medicines, including the contraceptive pill, anticoagulants (like warfarin), and anti-epilepsy drugs. Do not start this herbal remedy without a pharmacist checking your current medications.

Sindrome serotoninergica

Taking St John's wort with other antidepressants (such as SSRIs) can cause serotonin syndrome, a potentially life-threatening condition involving high body temperature, agitation, and muscle rigidity.

Malattia renale

If you have severe kidney problems, your body may not be able to remove excess magnesium, leading to dangerously high levels in the blood. Check with your doctor before use.

Photosensitivity

St John's wort can make your skin significantly more sensitive to sunlight, leading to severe sunburn or skin reactions even with limited exposure.

Alcol

It is best to avoid or strictly limit alcohol while taking St John's wort. Both substances can cause drowsiness and affect your coordination; combining them increases these effects and may impact your mental health.

It is best to avoid or strictly limit alcohol when taking magnesium. Alcohol acts as a diuretic, which can increase the amount of magnesium your body loses through urine, potentially making the supplement less effective. Additionally, chronic alcohol use can lead to magnesium deficiency.

Prodotti lattiero-caseari (Latte, Formaggio, Yogurt)

Avoid taking magnesium supplements at the same time as large amounts of dairy products. Dairy is high in calcium, and high doses of calcium can compete with magnesium for absorption in the gut, meaning you may not get the full benefit of your supplement. It is best to space them at least 2 hours apart.

Caffeina (Caffè, Tè, Bevande energetiche)

St John's wort can increase sensitivity to caffeine. This may lead to feelings of anxiety, restlessness, or a racing heart.

It is best to limit caffeine intake around the time you take magnesium. Like alcohol, caffeine has a mild diuretic effect and can increase the excretion of magnesium through the kidneys.

Foods high in Tyramine (Aged cheeses, cured meats, soy sauce, overripe fruits)

While rare with modern preparations, St John's wort may interact with tyramine-rich foods, potentially causing a sudden increase in blood pressure. If you experience a severe headache or chest pain after eating these foods, seek medical advice.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.

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Storia dell'articolo

Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.

  • 25 Gen 2026 | Pubblicato originariamente
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