Can I take Co-codamol and Mirtazapine together?

Assumere co-codamol e mirtazapina should be done with caution as taking them together can make you feel very sleepy, dizzy, and confused.

Do not drive, operate machinery, or perform tasks that require you to be alert until you know how these medicines affect you.

Avoid drinking alcohol, as this will make the sleepiness much worse. If you feel extremely drowsy or have difficulty breathing, seek medical help immediately.

Perché succede

Both medicines affect the central nervous system (the brain). Co-codamol contains codeine (an opioid) and mirtazapine is an antidepressant; both have sedative effects. When taken together, these effects add up (an 'additive effect'), making the side effects of both drugs much stronger.

You may be experiencing an interaction between co-codamol (codeine and paracetamol) and mirtazapine if:

• You feel excessively sleepy, drowsy, or sedated.

• You experience dizziness, confusion, or difficulty concentrating.

• You notice slowed breathing or shallow breathing.

• You have poor coordination or balance, increasing the risk of falls.

• You develop constipation or difficulty passing urine.

• Symptoms start soon after taking both medicines together or after a dose increase.

Se hai uno dei sintomi sopra elencati, dovresti:

• Contact your GP or pharmacist for advice as soon as possible.

• Do not stop mirtazapine or co-codamol suddenly unless advised by a healthcare professional.

• Seek urgent medical help if you experience slowed breathing, severe drowsiness, or confusion.

• Avoid driving or operating machinery until you know how the combination affects you.

• Informa il tuo professionista sanitario su tutti gli altri medicinali e integratori che stai assumendo.

Suicidal thoughts or worsening depression

Mirtazapine can occasionally cause an increase in suicidal thoughts or self-harm, particularly when first starting treatment or changing the dose. Seek immediate medical help if your mood worsens or you have distressing thoughts.

Agranulocitosi (basso numero di globuli bianchi)

Mirtazapine can rarely cause a serious drop in white blood cells. You must contact a doctor immediately if you develop signs of infection, such as a high temperature, sore throat, or mouth ulcers.

Paracetamol overdose

Co-codamol contains paracetamol. Do not take it with any other paracetamol-containing products (such as cold and flu remedies), as this can lead to overdose and potentially fatal liver damage.

Opioid addiction and withdrawal

Co-codamol contains codeine, which can cause addiction if used for more than 3 days. Stopping suddenly after long-term use can cause withdrawal symptoms.

Breathing difficulties

Do not take co-codamol if you have severe asthma or breathing problems, as the codeine can dangerously slow your breathing.

Alcol

You must avoid or strictly limit alcohol while taking these medicines. Both co-codamol and mirtazapine cause drowsiness and slow your reactions. Alcohol significantly increases these effects, which can lead to dangerous levels of sedation, breathing difficulties, and an increased risk of falls or accidents.

Caffeina

While there is no direct 'danger' interaction, mirtazapine can sometimes cause increased appetite or weight gain. Additionally, if you are taking mirtazapine for anxiety or sleep, high amounts of caffeine may counteract the calming effects of the medicine. Some branded versions of co-codamol may already contain caffeine; check the packaging to avoid excessive intake which can cause jitters or heart palpitations.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.