EGF-like fibulin extracellular matrix protein 2
Ultimo aggiornamento 18 Nov 2025
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
The EFEMP2 gene provides instructions for making a protein called EGF-containing fibulin-like extracellular matrix protein 2, which is also known as fibulin-4. This protein is part of a group of proteins called fibulins. Fibulins have a variety of functions in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
Normal function
The EFEMP2 gene provides instructions for making a protein called EGF-containing fibulin-like extracellular matrix protein 2, which is also known as fibulin-4. This protein is part of a group of proteins called fibulins. Fibulins have a variety of functions in the extracellular matrix, which is the intricate lattice of proteins and other molecules that forms in the spaces between cells.
Little is known about the function of fibulin-4 in the extracellular matrix. It appears to play a critical role in the assembly of elastic fibers, which are slender bundles of protein that provide strength and flexibility to connective tissue (tissue that supports the body's joints and organs). Fibulin-4 is found in tissues and organs that are rich in elastic fibers, including the blood vessels, heart valves, lungs, and skin.
Conditions referring to this gene or chromosome
Altri nomi
EGF containing fibulin extracellular matrix protein 2
EGF containing fibulin like extracellular matrix protein 2
EGF containing fibulin-like extracellular matrix protein 2
EGF-containing fibulin-like extracellular matrix protein 2
FBLN4
fibulin 4
fibulin-like extracellular matrix protein
MBP1
mutant p53 binding protein 1
UPH1
Related patient information and medicines
Patient information leaflet
Posso prendere Mirabegron e Rivaroxaban insieme?
Why this happens Mirabegron and rivaroxaban are processed b... Mirabegron is primarily broken down by enzymes called CYP3A4 and CYP2D6, while rivaroxaban is processed by CYP3A4 and a transport protein called P-gp. While they share the CYP3A4 pathway, studies show that mirabegron does not significantly change the levels of drugs like rivaroxaban in.
Patient information leaflet
Test genetici
Test genetici is a type of medical test that identifies changes in chromosomes, genes or proteins. Genetic tests examine a person's DNA in a variety of ways to assess a person's genetic health. They are all designed to identify a particular gene that may cause a genetic disorder. Sometimes a gene may change (this is called a mutation) and either.
Patient information leaflet
Alimentazione sana
Sano eating may help to prevenire certain long-term (chronic) diseases come heart disease, stroke and diabetes. What are the benefits of healthy eating. Healthy eating may help to prevent certain serious diseases such as heart disease , stroke and type 2 diabetes. It may also help to reduce your risk of developing some cancers. You obtain this.
Patient information leaflet
Posso assumere olio di CBD e Clozapina insieme?
Assumere CBD oil with clozapine can significantly increase the levels of clozapine in your blood. This can lead to serious side effects such as extreme drowsiness, dizziness, seizures, or a ... Additionally, both substances can cause sleepiness, which may be much worse when they are taken together. Why this happens Clozapina is broken down in the.
Patient information leaflet
Malattia renale diabetica
Diabetic kidney disease (diabetic nephropathy) is a complication that occurs in some people with diabetes. Diabetic kidney disease is one of the causes of chronic kidney disease , a long-term condition where the kidneys do not work as well as they should. In diabetic kidney disease, the filters of the kidneys, the glomeruli, become damaged..
Patient information leaflet
Vaccini e allergie alle uova
Some types of vaccine are made using a process that involves chicken eggs or chicken embryos, and contain small amounts of egg protein. Egg allergy is one of the most common food allergies, especially in children. In the past, people with egg allergies have been told to avoid having any vaccines made with chicken eggs, due to concerns about.
Ulteriori letture e riferimenti
- EGF-like fibulin extracellular matrix protein 2; MedlinePlus, National Library of Medicine.
- Dasouki M, Markova D, Garola R, Sasaki T, Charbonneau NL, Sakai LY, Chu ML. Compound heterozygous mutations in fibulin-4 causing neonatal lethal pulmonary artery occlusion, aortic aneurysm, arachnodactyly, and mild cutis laxa. Am J Med Genet A. 2007 Nov 15;143A(22):2635-41. doi: 10.1002/ajmg.a.31980.
- Giltay R, Timpl R, Kostka G. Sequence, recombinant expression and tissue localization of two novel extracellular matrix proteins, fibulin-3 and fibulin-4. Matrix Biol. 1999 Oct;18(5):469-80. doi: 10.1016/s0945-053x(99)00038-4.
- Hucthagowder V, Sausgruber N, Kim KH, Angle B, Marmorstein LY, Urban Z. Fibulin-4: a novel gene for an autosomal recessive cutis laxa syndrome. Am J Hum Genet. 2006 Jun;78(6):1075-80. doi: 10.1086/504304. Epub 2006 Apr 10.
- Kielty CM. Elastic fibres in health and disease. Expert Rev Mol Med. 2006 Aug 8;8(19):1-23. doi: 10.1017/S146239940600007X.
- Kobayashi N, Kostka G, Garbe JH, Keene DR, Bachinger HP, Hanisch FG, Markova D, Tsuda T, Timpl R, Chu ML, Sasaki T. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem. 2007 Apr 20;282(16):11805-16. doi: 10.1074/jbc.M611029200. Epub 2007 Feb 26.
- Timpl R, Sasaki T, Kostka G, Chu ML. Fibulins: a versatile family of extracellular matrix proteins. Nat Rev Mol Cell Biol. 2003 Jun;4(6):479-89. doi: 10.1038/nrm1130.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.