ATP binding cassette subfamily C member 9
Ultimo aggiornamento 19 Nov 2025
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L ABCC9 gene provides instructions for making the sulfonylurea receptor 2 (SUR2) protein. This protein forms one part (subunit) of a channel that transports charged atoms of potassium (potassium ions) across cell membranes. Each of these channels consists of eight subunits: four SUR2 proteins and four proteins produced from either the KCNJ8 oppure KCNJ11 gene. The SUR2 subunits regulate the activity of the channel, determining whether it is open or closed.
Normal function
L ABCC9 gene provides instructions for making the sulfonylurea receptor 2 (SUR2) protein. This protein forms one part (subunit) of a channel that transports charged atoms of potassium (potassium ions) across cell membranes. Each of these channels consists of eight subunits: four SUR2 proteins and four proteins produced from either the KCNJ8 oppure KCNJ11 gene. The SUR2 subunits regulate the activity of the channel, determining whether it is open or closed.
Channels made with the SUR2 protein are known as ATP-sensitive potassium (K-ATP) channels. The channels open and close in response to the amount of ATP, the cell's main energy source, inside the cell. The resulting transport of potassium ions is part of a complex network of signals that relay chemical messages into and out of cells.
Although K-ATP channels are present in cells and tissues throughout the body, the highest levels of SUR2-containing channels are found in skeletal and heart (cardiac) muscle. These channels indirectly help regulate the concentration of calcium ions in cells. This regulation is essential for normal heart function. The function of these channels in other tissues is unclear.
Conditions referring to this gene or chromosome
Altri nomi
ABC37
ABCC9_HUMAN
ATFB12
ATP-binding cassette sub-family C member 9
ATP-binding cassette sub-family C member 9 isoform SUR2A
ATP-binding cassette sub-family C member 9 isoform SUR2B
ATP-binding cassette transporter sub-family C member 9
ATP-binding cassette, sub-family C (CFTR/MRP), member 9
CANTU
CMD1O
sulfonylurea receptor 2
SUR2
Related patient information and medicines
Patient information leaflet
Posso prendere Atorvastatina e integratori di fibre insieme?
This means the statin may not work as well to lower your cholesterol. Why this happens Fibre supplements (like psyllium husk or methylcellulose) can bind to the atorvastatin in your stomach or intestines, preventing it da entering your bloodstream. What you should do You do not need to stop taking fibre, but you should separate the doses. Our.
Patient information leaflet
Sindrome nefrosica
Parts of the body, particularly the feet and ankles, appear puffy and swollen. A high blood level of cholesterol and other fats (lipids). This is due to the change in the balance of various protein levels in the blood due to protein leakage. Normal kidney function, at least initially. This means that the 'waste clearing' function of the kidneys is.
Patient information leaflet
Il sistema immunitario
We are surrounded by millions of bacteria, viruses e altri germi (microbes) that have the potential to enter our bodies and cause harm. The immune system is the body's defence against disease-causing microbes (pathogens). The immune system is made up of non-specialised defences such as your skin (acting as a barrier) and strong acid stomach.
Patient information leaflet
Esami del sangue
Cellule del sangue sono made in the bone mar. Blood cells are divided into three main types: Red cells (erythrocytes) These make blood a red colour. One drop of blood contains about five million red cells. A constant new supply of red blood cells is needed to replace old cells that break down. Millions of red blood cells are made each day. Red cells.
Patient information leaflet
Posso prendere Bisoprololo e integratori di fibre insieme?
Taking them without enough liquid can cause the supplement to swell a... Using other medicines Taking multiple medicines. Our Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do.
Patient information leaflet
Posso prendere Atorvastatina e Biotina insieme?
There is no known interaction between atorvastatin and biotin. It is generally considered safe to take these two together. Why this happens Atorvastatin is processed by specific liver enzymes (CYP3A4), while biotin (Vitamin B7) is a water-soluble vitamin that uses different pathways for absorption and processing. They do not interfere with each.
Ulteriori letture e riferimenti
- ATP binding cassette subfamily C member 9; MedlinePlus, National Library of Medicine.
- Bienengraeber M, Olson TM, Selivanov VA, Kathmann EC, O'Cochlain F, Gao F, Karger AB, Ballew JD, Hodgson DM, Zingman LV, Pang YP, Alekseev AE, Terzic A. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet. 2004 Apr;36(4):382-7. doi: 10.1038/ng1329. Epub 2004 Mar 21.
- Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit-Drews P, Aguilar-Bryan L. ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007 Feb;453(5):703-18. doi: 10.1007/s00424-006-0116-z. Epub 2006 Aug 8.
- Harakalova M, van Harssel JJ, Terhal PA, van Lieshout S, Duran K, Renkens I, Amor DJ, Wilson LC, Kirk EP, Turner CL, Shears D, Garcia-Minaur S, Lees MM, Ross A, Venselaar H, Vriend G, Takanari H, Rook MB, van der Heyden MA, Asselbergs FW, Breur HM, Swinkels ME, Scurr IJ, Smithson SF, Knoers NV, van der Smagt JJ, Nijman IJ, Kloosterman WP, van Haelst MM, van Haaften G, Cuppen E. Dominant missense mutations in ABCC9 cause Cantu syndrome. Nat Genet. 2012 May 18;44(7):793-6. doi: 10.1038/ng.2324.
- Solbach TF, Konig J, Fromm MF, Zolk O. ATP-binding cassette transporters in the heart. Trends Cardiovasc Med. 2006 Jan;16(1):7-15. doi: 10.1016/j.tcm.2005.10.001.
- van Bon BW, Gilissen C, Grange DK, Hennekam RC, Kayserili H, Engels H, Reutter H, Ostergaard JR, Morava E, Tsiakas K, Isidor B, Le Merrer M, Eser M, Wieskamp N, de Vries P, Steehouwer M, Veltman JA, Robertson SP, Brunner HG, de Vries BB, Hoischen A. Cantu syndrome is caused by mutations in ABCC9. Am J Hum Genet. 2012 Jun 8;90(6):1094-101. doi: 10.1016/j.ajhg.2012.04.014. Epub 2012 May 17.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.