Policitemia vera
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Polycythemia vera is a condition characterised by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells and platelets cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.
Descrizione
Polycythemia vera is a condition characterised by an increased number of red blood cells in the bloodstream. Affected individuals may also have excess white blood cells and blood clotting cells called platelets. These extra cells and platelets cause the blood to be thicker than normal. As a result, abnormal blood clots are more likely to form and block the flow of blood through arteries and veins. Individuals with polycythemia vera have an increased risk of deep vein thrombosis (DVT), a type of blood clot that occurs in the deep veins of the arms or legs. If a DVT travels through the bloodstream and lodges in the lungs, it can cause a life-threatening clot known as a pulmonary embolism (PE). Affected individuals also have an increased risk of heart attack and stroke caused by blood clots in the heart and brain.
Polycythemia vera typically develops in adulthood, around age 60, although in rare cases it occurs in children and young adults. This condition may not cause any symptoms in its early stages. Some people with polycythemia vera experience headaches, dizziness, ringing in the ears (tinnitus), impaired vision, or itchy skin. Affected individuals frequently have reddened skin because of the extra red blood cells. Other complications of polycythemia vera include an enlarged spleen (splenomegaly), stomach ulcers, gout (a form of arthritis caused by a buildup of uric acid in the joints), heart disease, and cancer of blood-forming cells (leukemia).
Modelli di ereditarietà
The source lists the following possible inheritance patterns: Autosomal dominant; Not inherited. More than one pattern can apply in different cases.
Related genes
Altri nomi
Osler-Vaquez disease
Polycythemia ruba vera
Primary polycythemia
PRV
PV
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Policitemia rubra vera
Polycythaemia rubra vera (PRV) is a myeloproliferative disorder, which means the bone marrow makes too many blood cells. It is also sometimes just called polycythaemia (PV). There is an abnormally high number of red blood cells in your blood. You may also have an abnormally high number of platelets and white blood cells. Polycythaemia rubra vera.
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Mielofibrosi is a condition affecting the bone marrow and its blood cell production. The bone marrow is normally spongy but myelofibrosis causes the bone marrow to become s... Secondary myelofibrosis can be caused by other conditions such as essential thrombocythaemia oppure polycythaemia rubra vera. It has also been linked to exposure to some.
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Ulcere della bocca
A small sample (biopsy) of the ulcer may be taken in clinic and examined, to exclude cancer. Frequently asked questions Can I cure mouth ulcers naturally. Rinsing your mouth with saltwater, applying honey or aloe vera, and avoiding spicy or acidic foods can help ulcers heal faster and reduce pain. Why do I keep getting mouth ulcers. Mouth ulcers.
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Punture di zanzara
Zika. See the leaflet on Zika Virus for more information. Dengue. See the leaflet on Dengue for more information. West Nile virus : Found in Africa, North America, West Asia, Europe and the Middle East, West Nile virus is transmitted by the Culex mosquito. West Nile virus can be fatal. Symptoms of the most severe version of the virus can include.
Medicine leaflet
Compresse di Melphalan
About melphalan tablets Type of medicine An alkylating chemotherapy medicine Used for Multiple myeloma; polycythaemia vera Available as Tablets Melphalan is used to treat some cancers and conditions where cells in the body rap... Polycythaemia vera is a bone marrow disease that leads to an abnormal increase in the number of red blood cells in the.
Ulteriori letture e riferimenti
- Policitemia vera; MedlinePlus, National Library of Medicine.
- Cario H, McMullin MF, Pahl HL. Clinical and hematological presentation of children and adolescents with polycythemia vera. Ann Hematol. 2009 Aug;88(8):713-9. doi: 10.1007/s00277-009-0758-y. Epub 2009 May 26.
- Delhommeau F, Jeziorowska D, Marzac C, Casadevall N. Molecular aspects of myeloproliferative neoplasms. Int J Hematol. 2010 Mar;91(2):165-73. doi: 10.1007/s12185-010-0530-z. Epub 2010 Feb 27.
- Gangat N, Strand J, Lasho TL, Finke CM, Knudson RA, Pardanani A, Li CY, Ketterling RP, Tefferi A. Cytogenetic studies at diagnosis in polycythemia vera: clinical and JAK2V617F allele burden correlates. Eur J Haematol. 2008 Mar;80(3):197-200. doi: 10.1111/j.1600-0609.2007.01003.x. Epub 2007 Dec 7.
- Landolfi R, Nicolazzi MA, Porfidia A, Di Gennaro L. Polycythemia vera. Intern Emerg Med. 2010 Oct;5(5):375-84. doi: 10.1007/s11739-010-0369-6. Epub 2010 Mar 16.
- Mehta J, Wang H, Iqbal SU, Mesa R. Epidemiology of myeloproliferative neoplasms in the United States. Leuk Lymphoma. 2014 Mar;55(3):595-600. doi: 10.3109/10428194.2013.813500. Epub 2013 Jul 29.
- Tefferi A. Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1. Leukemia. 2010 Jun;24(6):1128-38. doi: 10.1038/leu.2010.69. Epub 2010 Apr 29.
- Thiele J, Kvasnicka HM. The 2008 WHO diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Curr Hematol Malig Rep. 2009 Jan;4(1):33-40. doi: 10.1007/s11899-009-0005-6.
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