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Can I take Vitamin B2 and Vitamin C together?

Drug interaction guide

Originally published 25 Jan 2026

Meets Patient’s editorial guidelines

There is no evidence of a harmful interaction between Vitamin B2 (riboflavin) and Vitamin C (ascorbic acid). In fact, these two vitamins are often found together in multivitamin supplements and naturally in many fruits and vegetables.

Why this happens

Vitamin B2 and Vitamin C are both water-soluble vitamins that are processed by the body in different ways. They do not compete for absorption in the gut, nor do they interfere with how each other is broken down or removed from the body. They have complementary roles in supporting the immune system and energy production.

What you should do

It is safe to take Vitamin B2 and Vitamin C together. You do not need to space them apart. As with all supplements, ensure you do not exceed the recommended daily allowance unless advised by a healthcare professional.

Important precautions

Kidney stones (oxalate)

High doses of vitamin C can increase the amount of oxalate in your urine, which significantly raises the risk of developing kidney stones, especially if you have had them before.

G6PD deficiency

If you have a G6PD deficiency (a genetic enzyme condition), high doses of vitamin C can cause your red blood cells to break down (haemolysis).

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking these vitamins. Alcohol can interfere with the absorption of Vitamin B2 and Vitamin C in the gut and increases the rate at which your body flushes them out, making the supplements less effective. Combining alcohol with any medicine also increases the risk of liver strain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.

  • 25 Jan 2026 | Originally published

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