Can I take Oestrogel pump-pack and Vitamin B12 together?

Why this happens

Oestrogel is a hormone replacement therapy (HRT) absorbed through the skin into the bloodstream. Vitamin B12 is a water-soluble vitamin involved in nerve function and blood cell production. They are processed by different pathways in the body and do not interfere with each other's effectiveness or safety.

You can continue to take your Vitamin B12 supplement while using Oestrogel as prescribed. No special precautions or timing adjustments are necessary.

Blood clots and breast cancer

You must not use Oestrogel if you have ever had breast cancer, or if you have ever had a blood clot in a vein (thrombosis) or the lungs (pulmonary embolism).

Oestrogel slightly increases your risk of blood clots (DVT/PE), stroke, and breast cancer. Seek immediate medical help if you experience sudden chest pain, breathlessness, or painful swelling in one leg.

Unexplained vaginal bleeding

Do not use Oestrogel if you have any vaginal bleeding that has not been checked and explained by your doctor.

Skin contact transfer

Do not allow other people, especially children, to come into contact with the area of skin where you applied the Oestrogel. Cover the area with clothing once dry to prevent accidental hormone transfer.

Alcohol

It is best to avoid or strictly limit alcohol while using Oestrogel. Drinking alcohol can increase the levels of oestrogen in your blood, which may increase the risk of side effects. Additionally, long-term alcohol consumption combined with Hormone Replacement Therapy (HRT) is linked to a higher risk of breast cancer.

It is best to avoid or strictly limit alcohol while taking Vitamin B12. Heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut and can reduce the amount of the vitamin stored in the liver.

Grapefruit juice

Grapefruit juice can interfere with how your body breaks down estradiol. This can lead to higher levels of the medicine in your bloodstream, potentially increasing the risk of side effects such as breast tenderness, nausea, or headaches.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.