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Can I take Levothyroxine and Liothyronine together?

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Taking these two medicines together increases the total amount of thyroid hormone in your body. This can lead to symptoms of an overactive thyroid (hyperthyroidism), such as a racing heart, feeling shaky, anxiety, or difficulty sleeping.

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Perché succede

Both levothyroxine (T4) and liothyronine (T3) are synthetic versions of thyroid hormones. Levothyroxine is converted by the body into T3, while liothyronine is already the active form. Using both at the same time has an additive effect on your thyroid hormone levels.

This combination is sometimes specifically prescribed by specialists (endocrinologists) for patients who do not feel well on levothyroxine alone. You should only take both if your doctor has explicitly told you to do so. Ensure you have regular blood tests to monitor your thyroid levels and report any symptoms like heart palpitations or excessive sweating to your GP.

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Heart conditions (e.g. angina, heart failure, or recent heart attack)

These medicines increase the workload on your heart. If you experience chest pain, palpitations, or shortness of breath, you must contact your doctor immediately as your dose may need to be adjusted more slowly.

Diabete

These medicines can raise blood sugar levels and may reduce the effectiveness of your diabetes medication. You must monitor your blood sugar more frequently when starting or changing your dose.

Adrenal gland insufficiency (untreated)

You must not start thyroid treatment until any adrenal gland problems are treated. Starting these medicines first can trigger a life-threatening medical emergency called an adrenal crisis.

Dairy products (Milk, Yogurt, Cheese)

Calcium found in dairy products can significantly interfere with the absorption of thyroid hormones. You should avoid consuming dairy within 4 hours of taking your medication.

Caffeine (Coffee, Tea)

Caffeine can reduce the amount of medicine your body absorbs. It is recommended to wait at least 30 to 60 minutes after taking your tablet before having a caffeinated drink.

Soya (Soybeans, Soy milk, Tofu)

Soya can interfere with how your body absorbs these medicines. If you eat a lot of soya, your doctor may need to monitor your thyroid levels more closely.

High-fibre foods

A very high-fibre diet (such as large amounts of bran or whole grains) can reduce the absorption of thyroid hormones. Try to keep your fibre intake consistent and discuss any major dietary changes with your doctor.

Papaya

Some studies suggest that eating papaya may interfere with the absorption of levothyroxine. It is best to avoid eating large amounts of papaya close to the time you take your dose.

Walnuts

Walnuts may reduce the absorption of thyroid medication. Avoid eating walnuts at the same time as taking your medicine.

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Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.

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Storia dell'articolo

Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.

  • 25 Gen 2026 | Pubblicato originariamente
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