Can I take Hydroxocobalamin and Stexerol D3 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There are no known harmful interactions between hydroxocobalamin and Stexerol-D3. It is safe to take these two medications together.
Why this happens
Hydroxocobalamin is a form of Vitamin B12, and Stexerol-D3 is a brand of Vitamin D3 (cholecalciferol). These vitamins are processed by different pathways in the body and do not interfere with each other's absorption, metabolism, or effectiveness.
What you should do
You can continue to take both medications as prescribed by your doctor. They are often prescribed together to treat different vitamin deficiencies.
Important precautions
Hypokalaemia (low potassium)
When starting treatment for severe vitamin B12 deficiency, your potassium levels can drop rapidly as your body produces new red blood cells. This can be dangerous for your heart and may require monitoring by your doctor.
Hypercalcaemia (high calcium) or kidney stones
Do not take Stexerol D3 if you have high levels of calcium in your blood or urine, or a history of kidney stones, as vitamin D3 increases calcium absorption and can worsen these conditions.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while receiving hydroxocobalamin treatment. Excessive alcohol consumption can interfere with the absorption of Vitamin B12 and may worsen the underlying deficiency being treated. Combining alcohol with medication also increases the risk of liver strain.
It is best to avoid or strictly limit alcohol while taking Stexerol D3. Long-term heavy alcohol use can interfere with how your body processes Vitamin D and may weaken your bones.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
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