Can I take Danazol and Lansoprazole together?

Why this happens

Lansoprazole is a proton pump inhibitor (PPI) that increases gastric pH. Danazol is a highly lipophilic drug with pH-dependent solubility; a more alkaline environment in the stomach can significantly decrease its dissolution and subsequent absorption.

What you should do

Speak to your doctor or pharmacist before taking these together. They may suggest monitoring your symptoms more closely to ensure the danazol is still working, or they may recommend a different way to manage your stomach acid.

Important precautions

Pregnancy

You must not take danazol if you are pregnant or planning to become pregnant. It can cause the development of male physical characteristics in a female fetus. You must use effective, non-hormonal contraception (such as condoms) while taking it.

Blood clots (Thromboembolism)

Danazol significantly increases the risk of serious blood clots. Seek immediate medical help if you experience sudden leg swelling, chest pain, or shortness of breath.

Liver disease

Danazol can cause serious liver damage and non-cancerous liver tumours. You will need regular blood tests to monitor your liver function while taking this medicine.

Severe diarrhoea

Lansoprazole can increase your risk of serious bowel infections. If you develop severe or persistent watery diarrhoea, or a fever, contact your doctor immediately and do not take anti-diarrhoeal medicine.

Lupus (SLE) or skin reactions

Contact your doctor if you develop a skin rash, especially in areas exposed to the sun, as lansoprazole can cause a rare but serious autoimmune skin reaction.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking danazol. Combining danazol with alcohol can cause you to feel nauseous or short of breath (a disulfiram-like reaction). Additionally, both danazol and alcohol can put strain on your liver, and using them together increases the risk of liver damage.

It is best to avoid or strictly limit alcohol while taking lansoprazole. Alcohol increases the amount of acid your stomach produces, which can make your symptoms worse and counteract the effects of the medicine.

Caffeine (Coffee, Tea, Energy Drinks)

While there is no direct chemical interaction, lansoprazole is often prescribed to treat acid reflux or stomach ulcers. Caffeine can increase stomach acid production and irritate the stomach lining, which may prevent the medicine from working effectively to manage your symptoms.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.