Posso prendere Atorvastatina e Rivaroxaban insieme?

Perché succede

Both medications are processed by the same enzyme system in the liver (CYP3A4) and a transport protein (P-gp). Because they compete for these systems, atorvastatin can slow down the breakdown of rivaroxaban, leading to slightly higher levels of the blood thinner in your body.

It is generally safe to take these two medicines together, as the interaction is usually mild. However, you should be vigilant for any signs of unusual bleeding or bruising. If you notice blood in your urine, black tarry stools, or a nosebleed that won't stop, contact your doctor immediately. Ensure your doctor knows you are taking both, especially if your dose of atorvastatin is increased.

Gravidanza

Non devi assumere atorvastatina se sei incinta o stai pianificando di diventare incinta, poiché può causare gravi danni a un bambino non ancora nato. Usa un contraccettivo efficace mentre prendi questo medicinale.

Disturbi muscolari - atorvastatina

Consultare immediatamente un medico se si avverte dolore muscolare inspiegabile, sensibilità o debolezza. In rari casi, ciò può portare a una condizione grave chiamata rabdomiolisi che causa danni ai reni.

Active bleeding or high bleeding risk

Rivaroxaban significantly increases your risk of serious bleeding. You must seek immediate medical help if you have a fall or head injury, or if you notice signs of internal bleeding such as black tarry stools or coughing up blood.

Succo di pompelmo

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcol

While there is no direct interaction, drinking large amounts of alcohol can increase the risk of liver problems with atorvastatin and increase the risk of stomach bleeding with rivaroxaban. It is best to stick to the recommended daily limits.

Food (General) - rivaroxaban

The 15mg and 20mg tablets must be taken with food to ensure the medicine is absorbed properly into your body. If taken on an empty stomach, the medicine may not work as well. The 2.5mg and 10mg doses can be taken with or without food.

Taking multiple medicines? Our Controllo Interazioni Farmaci helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Avvertenza

Queste informazioni sono solo a scopo educativo generale e non devono essere considerate un sostituto del consiglio medico professionale. Consultate sempre il vostro medico di base, farmacista o un altro professionista sanitario qualificato prima di prendere decisioni sui vostri farmaci. Le circostanze individuali possono variare, e solo un professionista sanitario che conosce la vostra storia medica può fornire una guida personalizzata.