potassium voltage-gated channel subfamily Q member 3
Ultimo aggiornamento 18 Ago 2020
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L KCNQ3 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
Normal function
L KCNQ3 gene belongs to a large family of genes that provide instructions for making potassium channels. These channels, which transport positively charged atoms (ions) of potassium into and out of cells, play a key role in a cell's ability to generate and transmit electrical signals.
The specific function of a potassium channel depends on its protein components and its location in the body. Channels made with the KCNQ3 protein are active in nerve cells (neurons) in the brain, where they transport potassium ions out of cells. These channels transmit a particular type of electrical signal called the M-current, which prevents the neuron from continuing to send signals to other neurons. The M-current ensures that the neuron is not constantly active, or excitable.
Potassium channels are made up of several protein components (subunits). Each channel contains four alpha subunits that form the hole (pore) through which potassium ions move. Four alpha subunits from the KCNQ3 gene can form a channel. However, the KCNQ3 alpha subunits can also interact with alpha subunits from the KCNQ2 gene to form a functional potassium channel, and these channels transmit a much stronger M-current.
Conditions referring to this gene or chromosome
Altri nomi
BFNC2
EBN2
KCNQ3_HUMAN
KV7.3
potassium channel subunit alpha KvLQT3
potassium channel, voltage gated KQT-like subfamily Q, member 3
potassium channel, voltage-gated, subfamily Q, member 3
potassium voltage-gated channel subfamily KQT member 3
potassium voltage-gated channel, KQT-like subfamily, member 3
voltage-gated potassium channel subunit Kv7.3
Related patient information and medicines
Patient information leaflet
Sindrome da refeeding
Refeeding syndrome was first described in Far East prisoners after the second world war when they developed heart failure after starting to eat again after a prolonged period of starvation. Refeeding syndrome is a dangerous and life threatening shift of fluids and body salts (electrolytes) that can occur when malnourished patients receive.
Patient information leaflet
Posso prendere Bisoprololo e Ramipril insieme?
Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while ramipril è an ACE inhibitor that relaxes blood vessels. Because they both target the cardiovascular system, their effects add together (an additive effect). It is best to keep ... Salt substitutes.
Patient information leaflet
Lesione renale acuta
Lesione renale acuta can be a confusing name as it suggests an accident or injury to that part of your body, eg from a fall or trauma. However, acute kidney injury is actually a condition where your kidneys suddenly stop working properly. If you have acute kidney injury (AKI) your kidneys suddenly stop working as well as they should. This means the.
Patient information leaflet
Posso prendere Co-amoxiclav e Ramipril insieme?
Assumere co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). It may also increase the risk of high potassium levels in the blood or affect your kidney function, especially if you are already unwell with an infection. Our Medicines Interaction.
Patient information leaflet
Bulimia nervosa
Bulimia is an eating disorder. People with bulimia nervosa have episodes of binge eating. This is followed by deliberately fasting, making themselves sick, excessive exercise or other measures to counteract the excessive food intake. What is bulimia. Bulimia nervosa (often just called bulimia) is an eating disorder where you have a distorted view.
Patient information leaflet
Posso prendere Bisoprololo e Losartan insieme?
Assumere bisoprolol and losartan together can cause your la pressione sanguigna per drop lower than intended. This may make you feel dizzy, lightheaded, or faint, especially when standing up quickly. It can also lead to increased levels of potassium in your blood. Why this happens Both medicines work to lower blood pressure but in different ways. Bisoprolol.
Ulteriori letture e riferimenti
- potassium voltage-gated channel subfamily Q member 3; MedlinePlus, National Library of Medicine.
- Chung HJ, Jan YN, Jan LY. Polarized axonal surface expression of neuronal KCNQ channels is mediated by multiple signals in the KCNQ2 and KCNQ3 C-terminal domains. Proc Natl Acad Sci U S A. 2006 Jun 6;103(23):8870-5. doi: 10.1073/pnas.0603376103. Epub 2006 May 30.
- Rogawski MA. KCNQ2/KCNQ3 K+ channels and the molecular pathogenesis of epilepsy: implications for therapy. Trends Neurosci. 2000 Sep;23(9):393-8. doi: 10.1016/s0166-2236(00)01629-5.
- Schroeder BC, Kubisch C, Stein V, Jentsch TJ. Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy. Nature. 1998 Dec 17;396(6712):687-90. doi: 10.1038/25367.
- Singh NA, Westenskow P, Charlier C, Pappas C, Leslie J, Dillon J, Anderson VE, Sanguinetti MC, Leppert MF; BFNC Physician Consortium. KCNQ2 and KCNQ3 potassium channel genes in benign familial neonatal convulsions: expansion of the functional and mutation spectrum. Brain. 2003 Dec;126(Pt 12):2726-37. doi: 10.1093/brain/awg286. Epub 2003 Oct 8.
- Soldovieri MV, Miceli F, Bellini G, Coppola G, Pascotto A, Taglialatela M. Correlating the clinical and genetic features of benign familial neonatal seizures (BFNS) with the functional consequences of underlying mutations. Channels (Austin). 2007 Jul-Aug;1(4):228-33. doi: 10.4161/chan.4823. Epub 2007 Aug 2.
- Wang HS, Pan Z, Shi W, Brown BS, Wymore RS, Cohen IS, Dixon JE, McKinnon D. KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel. Science. 1998 Dec 4;282(5395):1890-3. doi: 10.1126/science.282.5395.1890.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.