complement C8 alpha chain
Ultimo aggiornamento 18 Ago 2020
Rispetta le linee guida editoriali
- ScaricaScarica
- Condividi
- Language
- Discussione
- Versione audio
- Aggiungi alle fonti preferite su Google
L C8A gene provides instructions for making one piece, the alpha subunit, of a protein complex called complement component 8. The alpha subunit is linked to another piece of the complex called the gamma subunit (produced from the C8G gene). These two proteins interact with the beta subunit (produced from the C8B gene) to form complement component 8.
Normal function
L C8A gene provides instructions for making one piece, the alpha subunit, of a protein complex called complement component 8. The alpha subunit is linked to another piece of the complex called the gamma subunit (produced from the C8G gene). These two proteins interact with the beta subunit (produced from the C8B gene) to form complement component 8.
Complement component 8 aids in a part of the body's immune response known as the complement system. The complement system is a group of proteins that work together to destroy foreign invaders, trigger inflammation, and remove debris from cells and tissues. Complement component 8 combines with several other complement proteins to form the membrane attack complex (MAC), which inserts itself in the outer membrane of bacterial cells. This complex creates a hole (pore) in the membrane, which kills the bacterium. This part of the immune response appears to be especially important for fighting infection by bacteria in the Neisseria genus.
Conditions referring to this gene or chromosome
Altri nomi
complement component 8 alpha subunit
complement component 8 subunit alpha
complement component 8, alpha polypeptide
complement component C8 alpha chain preproprotein
Related patient information and medicines
Patient information leaflet
Talassemia
Depending on which type you have, thalassaemia may cause no illness at all, or may be a. What causes thalassaemia. Haemoglobin is located in cells called red blood cells which are ... Haemoglobin is made out of different parts. The main parts are called alpha chains and beta chains which are put insieme to make the haemoglobin molecule. In.
Patient information leaflet
Posso prendere Colecalciferolo e Doxazosina insieme?
Non ci sono no known significant interactions between colecalciferol (Vitamin D3) and doxazosin. Perché succede Colecalciferol is a vitamin used to maintain calcium levels and bone health, while doxazosin is an alpha-blocker used to treat high blood pressure or an enlarged prostate. They are processed by different pathways in the body and do not.
Patient information leaflet
Cancro ai testicoli
Testicular cancer is a cancer that arises from a testicle (testis). Around half of all cases occur in men aged under 35 but testicular cancer rarely occurs before puberty. Another useful test i... The tumore markers commonly tested for are alpha-fetoprotein (AFP), beta human chorionic gonadotrophin (beta-hCG), lactic dehydrogenase (LDH) and.
Patient information leaflet
Artrite reumatoide
This is an uncommon but serious complication of severe, long-standing RA. Rheumatoid arthritis treatment Standards of care you should expect The National Institute for Health and Care Excellence (NICE) has published quality standards on the standard of care that should be offered to every adult over 16 who has RA. They state: If you have symptoms.
Patient information leaflet
Sindrome delle gambe senza riposo
Secondaria causi Sintomi di secondary RLS can develop as a complication of. For example: Pregnancy. About 1 in 5 pregnant women develop restless legs syndrome in pregnancy (especially in the later part of pregnancy). Symptoms often go away after a woman has given birth, but women who have RLS during pregnancy are four times as likely to develop.
Patient information leaflet
Medicina per la pressione alta
For detailed information about your own medication you should read the leaflet that comes inside the medicine packet. What are the types of blood pressure medicines. There are six main classes of medicines that are used to lower blood pressure: Angiotensin-converting enzyme (ACE) inhibitors. Angiotensin receptor blockers (ARBs). Calcium-channel.
Ulteriori letture e riferimenti
- complement C8 alpha chain; MedlinePlus, National Library of Medicine.
- Bubeck D. The making of a macromolecular machine: assembly of the membrane attack complex. Biochemistry. 2014 Apr 1;53(12):1908-15. doi: 10.1021/bi500157z. Epub 2014 Mar 18.
- Kaufman KM, Snider JV, Spurr NK, Schwartz CE, Sodetz JM. Chromosomal assignment of genes encoding the alpha, beta, and gamma subunits of human complement protein C8: identification of a close physical linkage between the alpha and the beta loci. Genomics. 1989 Oct;5(3):475-80. doi: 10.1016/0888-7543(89)90012-8.
- Kojima T, Horiuchi T, Nishizaka H, Fukumori Y, Amano T, Nagasawa K, Niho Y, Hayashi K. Genetic basis of human complement C8 alpha-gamma deficiency. J Immunol. 1998 Oct 1;161(7):3762-6.
- Merle NS, Noe R, Halbwachs-Mecarelli L, Fremeaux-Bacchi V, Roumenina LT. Complement System Part II: Role in Immunity. Front Immunol. 2015 May 26;6:257. doi: 10.3389/fimmu.2015.00257. eCollection 2015.
- Rosa DD, Pasqualotto AC, de Quadros M, Prezzi SH. Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis--case report and literature review. Braz J Infect Dis. 2004 Aug;8(4):328-30. doi: 10.1590/s1413-86702004000400010. Epub 2004 Nov 19.
Partecipa alla conversazione
Condividi i tuoi pensieri o esperienze con gli altri nel nostro comunità di pazienti.
Chiedi, condividi, connettiti.
Esplora le discussioni, fai domande e condividi esperienze su centinaia di argomenti di salute.
Iscriviti alla newsletter di Patient
La tua dose settimanale di consigli sulla salute chiari e affidabili - scritti per aiutarti a sentirti informato, sicuro e in controllo.
Abbonandoti accetti i nostri Informativa sulla Privacy. Puoi annullare l'iscrizione in qualsiasi momento. Non vendiamo mai i tuoi dati.