A Follow-on Study for Second-Eye Treatment for Participants Previously Treated With Gene Therapy for X-Linked Retinitis Pigmentosa (XLRP)

This study is specifically for male patients, both children and adults, who have already taken part in previous studies involving this gene therapy for X-linked Retinitis Pigmentosa (XLRP). You must have received the AAV5-hRKp.RPGR gene therapy in one eye already. If you haven't been part of those earlier studies, this particular follow-on study wouldn't be suitable for you.

To join, you need to sign a consent form. This form explains everything about the study clearly, so you understand what's involved and agree to take part. It's important that you also agree to follow the study's instructions and attend all the long-term check-ups.

There are no specific reasons that would automatically prevent you from joining this study, provided you meet the main criteria of having been in the previous related studies and agree to the terms.

Taking part in this study means you will receive the AAV5-hRKp.RPGR gene therapy in your second eye, following the treatment you've already had in your first eye. This involves a surgical procedure to deliver the gene therapy directly into your eye. After the procedure, you'll have regular follow-up appointments with the study doctors and nurses. These visits will involve various eye tests and check-ups to monitor your vision, the health of your eye, and to ensure the treatment is safe and well-tolerated. The total duration of your participation, including these follow-up assessments, will depend on what was agreed in the previous studies you were part of, as this is a continuation of that long-term monitoring. You won't be given any additional medication specifically for this study beyond the gene therapy itself and any standard care needed around the procedure.