Biological Determinants and Neural Compensation of Dysphagia in Parkinson's Disease

This study is looking for people who have been diagnosed with idiopathic Parkinson's disease. You can take part regardless of how long you've had Parkinson's or whether you currently have any swallowing problems – either that you notice yourself or that a doctor has identified. You need to be able to understand and follow study instructions, and you must be able to eat and drink normally by mouth.

However, there are some reasons why you wouldn't be able to join. If you have other medical conditions that can cause swallowing difficulties, such as a major stroke, certain cancers, or other brain injuries, this study isn't suitable for you. Also, if you have electronic devices in your body like a pacemaker or deep brain stimulator, or if you have conditions like asthma or severe lung problems, you wouldn't be able to participate due to safety reasons related to some of the tests.

This is an observational study, which means you won't be given any new treatments or medications. Instead, researchers will learn by carefully observing and collecting information about your health. You will have your swallowing thoroughly checked using a special flexible camera test (FEES), which is a common way to look at how you swallow. You'll also have a blood test to look for specific markers related to inflammation and brain health. Additionally, you will have a special type of brain scan called an fMRI, which looks at brain activity while you perform certain tasks, including swallowing. The study will also collect information about your Parkinson's symptoms, overall health, and how the condition affects your daily life. The total duration of your involvement will be explained by the study team.