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Genicular embolisation for knee osteoarthritis

This research is testing a new procedure called genicular artery embolisation (GAE) for people with persistent knee pain caused by osteoarthritis. Many people with knee osteoarthritis find themselves in a 'treatment gap' – their pain is too severe for simple treatments, but they're not yet at the stage where they need full knee replacement surgery. GAE works by blocking tiny extra blood vessels that form around the knee, which are thought to contribute to pain. Early results suggest it might help, and this larger study will compare GAE to a dummy treatment to see if it truly reduces pain effectively. If successful, it could offer a valuable new option for many.

A colpo d'occhio

Stato
Reclutamento
Sponsor
Università di Oxford
Obiettivo di iscrizione
216
Inizio
31 Lug 2025
Completamento stimato
30 Giugno 2027
Knee osteoarthritis

Di cosa tratta questo studio?

Knee osteoarthritis is a common condition that can cause a lot of pain and make everyday activities difficult. When the pain is mild, simple things like exercise and lifestyle changes can often help. For very severe cases, a knee replacement operation might be the best solution. However, many people find themselves in a difficult middle ground – their pain is significant, but they're not yet ready for major surgery, or other less invasive treatments haven't worked well enough.

This study, called GEKO, is looking into a new treatment called genicular artery embolisation (GAE). The idea behind GAE is to block off some of the tiny extra blood vessels that develop around a knee affected by osteoarthritis. These extra vessels are thought to play a part in causing pain. The procedure involves injecting tiny beads into these blood vessels to stop the extra blood flow.

Early studies have shown some promising results, suggesting that GAE could help reduce pain. This larger study is important because it will compare GAE with a 'dummy' treatment (a placebo) to see if it's truly effective and safe for people with ongoing knee osteoarthritis pain. If it proves to work well, it could provide a much-needed treatment option for many people who are currently struggling with pain.

Punti chiave

  • Tests a new treatment (GAE) for knee osteoarthritis pain.
  • Aims to relieve pain by blocking tiny blood vessels in the knee.
  • Compares GAE to a dummy treatment over 12 months.
  • For adults with persistent knee pain not ready for surgery.
  • Funded by a major UK health research body.
  • If successful, could offer a new option for many.

Chi può essere idoneo?

To join this study, you need to be an adult (18 or older) with a diagnosis of painful knee osteoarthritis. This means your doctor has confirmed you have knee osteoarthritis, and you've already tried some standard treatments without enough improvement.

It's important that your pain is moderate to severe, and you're not currently planned or considered for knee replacement surgery. The doctors will also check if the specific blood vessels in your knee are suitable for this embolisation procedure.

There are also some reasons why you might not be able to join, such as if you've had a steroid injection in that knee recently, have an infection or cancer around the knee, or have certain other medical conditions like severe kidney problems or a history of allergic reactions to dyes used in scans. If you are pregnant or breastfeeding, or have certain blood clotting issues, you also wouldn't be able to take part.

Questo studio potrebbe fare al caso tuo?

Rispondi a queste domande rapide per vedere se potresti essere idoneo. Questo è solo una guida — il team di ricerca prende la decisione finale.

  1. Sei un adulto (18 anni o più)?
  2. Do you have a confirmed diagnosis of painful knee osteoarthritis?
  3. Have you tried other treatments for your knee pain without enough success?
  4. Is your knee pain moderate to severe?
  5. Are you NOT currently scheduled or being considered for knee replacement surgery?
  6. Non sei incinta o stai allattando?
Rispondi a ogni domanda per vedere il tuo risultato.

Cosa comporta la partecipazione?

If you decide to take part in this study, you'll be randomly assigned to receive either the active treatment (GAE) or a dummy treatment (a saltwater injection). Neither you nor your study doctor will know which treatment you receive. The GAE procedure involves injecting tiny microbeads to block small blood vessels in your knee.

Taking part will involve having medical appointments and potentially one or two MRI scans of your knee. You'll also be asked to fill out questionnaires about your pain and how well your knee is working. These assessments will happen over a period of up to 12 months after your treatment to track your progress and see if the treatment has made a difference.

Rischi e benefici potenziali

There's a chance your knee pain might improve after the procedure, but there's no guarantee the treatment will work for you. As with any medical procedure, there's always a small risk of side effects or problems, and the medical team will discuss these with you in detail. You are free to withdraw from the study at any time, for any reason, without it affecting your usual medical care.

Luoghi (15)

Alcune posizioni dei siti sono approssimative. Stiamo migliorando questo — si prega di verificare con il team di prova prima di viaggiare.
  • Oxford University Hospitals NHS Foundation Trust
    Non verificato
    Oxford, England
  • Royal Cornwall Hospitals NHS Trust
    Non verificato
    Truro, England
  • Aneurin Bevan University Lhb
    Non verificato
    Newport, Wales
  • Trust NHS di North Bristol
    Non verificato
    Bristol, England
  • Imperial College Healthcare NHS Trust
    Non verificato
    London, England
  • Fondazione Trust degli Ospedali Universitari di Liverpool NHS
    Non verificato
    Liverpool, England
  • Hull University Teaching Hospitals NHS Trust
    Non verificato
    Hull, England
  • University Hospitals Coventry and Warwickshire NHS Trust
    Non verificato
    Coventry, England
  • Cambridge University Hospitals NHS Foundation Trust
    Non verificato
    Cambridge, England
  • Barts Health NHS Trust
    Non verificato
    London, England
  • Cardiff & Vale University Lhb
    Non verificato
    Cardiff, Wales
  • NHS Greater Glasgow e Clyde
    Non verificato
    Glasgow, Scotland

Domande comuni

What is genicular artery embolisation (GAE)?

GAE is a new procedure that involves blocking tiny extra blood vessels around your knee with small beads to help reduce pain from osteoarthritis.

Will I know if I'm getting the real treatment or the dummy treatment?

No, you won't know if you're receiving the active GAE treatment or a dummy (placebo) injection. This helps researchers fairly assess the treatment's effects.

Per quanto tempo sarò coinvolto nello studio?

You'll be followed up for up to 12 months after your treatment, with various check-ups and questionnaires.

Cosa succede se avverto effetti collaterali?

Your medical team will closely monitor you for any side effects and discuss any potential risks before you decide to take part.

Chi sta pagando per questo studio?

The study is funded by the National Institute for Health Research (NIHR) in the UK.

Come saperne di più

Debbie Jewell

debbie.jewell@ndorms.ox.ac.uk +44 (0)1865 613763 Registro ufficiale del processo

Parla sempre con il tuo medico di base o specialista prima di decidere di partecipare a uno studio.

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