A Study of the Efficacy and Safety of Brensocatib in Adults With Moderate to Severe Hidradenitis Suppurativa (HS)

To join this study, you need to be an adult between 18 and 80 years old, and you must have hidradenitis suppurativa (HS) that a skin doctor has confirmed. Your HS needs to have been present for at least six months and be considered moderate to severe, meaning you have at least six active painful lumps or pus-filled spots.

Your HS also needs to affect at least two different body areas, and at least one of these areas should be quite severe (what doctors call Hurley Stage II or III). You won't be able to join if you have many draining tunnels (20 or more) or if you've had surgery or laser treatment for your HS recently.

There are also some medical conditions and recent treatments that might prevent you from joining, such as certain blood conditions, active liver disease, or if you've recently taken certain strong antibiotics or other medicines for HS. This is to make sure the study is safe for everyone involved and that the results are clear.

If you decide to take part, you'll be assigned either to receive the study medicine (brensocatib) or a dummy medicine (placebo). You won't know which one you're getting, and neither will your study doctor. You'll need to visit the clinic regularly for check-ups, where the study team will monitor your HS, take blood samples, and ask about your health and any side effects. You might also need to keep a diary of your symptoms. The study will involve taking the medicine for a set period, followed by follow-up visits. The total duration of your involvement in the study will be explained in detail by the study team.