Long-term Safety of Nipple Sparing Mastectomy in Women With High Penetrance Breast Cancer Susceptibility Genes in Breast Cancer
This study is investigating the long-term safety of a type of breast surgery called nipple-sparing mastectomy. This operation allows women at high genetic risk of breast cancer to have a mastectomy (breast removal) to reduce their risk, while also keeping their nipple and the darker skin around it (areola). Many women prefer this option for their body image and well-being, but there isn't much long-term information yet on how safe it is, especially for preventing future cancers when compared to other types of mastectomy. This research aims to provide more clear answers by following women with specific genetic changes for a longer time, helping doctors give the best advice.
A colpo d'occhio
Di cosa tratta questo studio?
Imagine you have a strong family history of breast cancer, or genetic test results show you have a higher chance of developing it. One option some women consider is surgery to remove their breasts to significantly lower this risk. This is called a risk-reducing mastectomy.
There are different ways to do this surgery. Historically, the nipple and the skin around it were removed. However, a newer technique called 'nipple-sparing mastectomy' allows surgeons to remove the breast tissue, but keep the nipple and areola intact. Many women find that keeping these parts of their breast helps them feel much better about their body and reduces feelings of disfigurement after surgery.
Even though nipple-sparing mastectomy can have these important benefits for a woman's well-being, doctors still need more long-term information to be absolutely sure it's as safe as other types of mastectomy for cancer prevention, especially for women with certain genetic risks. This study aims to gather that important long-term safety data. By following women for a longer time, researchers hope to confirm whether this type of surgery is just as effective at preventing breast cancer in those at high genetic risk.
Punti chiave
- The study explores the long-term safety of nipple-sparing mastectomy.
- It's for women with specific genetic risks for breast cancer.
- The goal is to provide clearer evidence on this surgery for cancer prevention.
- Many women prefer this surgery for body image.
- More long-term data is needed for medical guidelines.
Chi può essere idoneo?
This study is looking for women who were assigned female at birth and are 18 years old or older. You would need to have had a genetic test that confirmed you carry specific changes in certain genes known to increase the risk of breast cancer. These genes include BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN.
You wouldn't be able to join if you have already had breast cancer, or if you had ovarian cancer before your genetic testing. Also, if you've already had both breasts removed before your genetic test, you wouldn't be suitable for this study. Finally, if your genetic test showed a 'variant of uncertain significance' – meaning genetic changes whose role isn't yet fully understood – as your only genetic finding, this study wouldn't be right for you.
Questo studio potrebbe fare al caso tuo?
Rispondi a queste domande rapide per vedere se potresti essere idoneo. Questo è solo una guida — il team di ricerca prende la decisione finale.
- I am a woman and was assigned female at birth.
- Ho 18 anni o più.
- I have had a genetic test that confirmed a specific genetic change (like BRCA1 or BRCA2) that increases my breast cancer risk.
- I have never had breast cancer before my genetic test.
- I have never had ovarian cancer before my genetic test.
- I have not had both breasts removed before my genetic test.
Cosa comporta la partecipazione?
The description does not provide details on what participation would involve in terms of visits, assessments, medication, or specific follow-up schedules. It mentions a focus on longer follow-up to confirm previous findings. To get a clear understanding of what joining this study would mean for you, you would need to speak directly with the research team.
Rischi e benefici potenziali
Locations (16)
- Università di YaleCodice postale verificatoNew Haven, Stati Uniti· Reclutamento
- Brigham and Women's Hospital - Dana-Farber Brigham Cancer CenterCodice postale verificatoBoston, Stati Uniti· Non ancora in fase di reclutamento
- Memorial Sloan Kettering Cancer Center (MSKCC)Codice postale verificatoNew York, Stati Uniti· Non ancora in fase di reclutamento
- University of Rochester, Wilmot Cancer InstituteCodice postale verificatoRochester, Stati Uniti· Non ancora in fase di reclutamento
- University of PennsylvaniaCodice postale verificatoPhiladelphia, Stati Uniti· Reclutamento
- University of Melbourne, Peter MacCallum Cancer CenterCodice postale verificatoMelbourne, Australia· Non ancora in fase di reclutamento
- Ziekenhuis Aan de StroomCodice postale verificatoAntwerp, Belgium· Attivo ma non reclutante
- Università di CalgaryCodice postale verificatoCalgary, Canada· Reclutamento
- Scienze della Salute di HamiltonCodice postale verificatoHamilton, Canada· Reclutamento
- Women's College Hospital, University of TorontoCodice postale verificatoToronto, Canada· Non ancora in fase di reclutamento
- Jewish General HospitalCodice postale verificatoMontreal, Canada· Reclutamento
- CHU de Quebec Université lavalCodice postale verificatoQuébec, Canada· Reclutamento
Domande comuni
What is a 'nipple-sparing mastectomy'?
It's a type of surgery where breast tissue is removed to reduce cancer risk, but the nipple and the darker skin around it (areola) are kept.
Perché questo studio è importante?
It aims to confirm if nipple-sparing mastectomy is a safe long-term option for preventing breast cancer in women with certain genetic risks, especially since many prefer this surgery for their well-being.
Who can take part in this research?
Women aged 18 or over, who have specific genetic changes (like in BRCA1/2 genes) that increase their breast cancer risk, and who haven't had breast or ovarian cancer before their genetic testing.
What genes are they looking at?
The study is looking at women with changes in genes like BRCA1, BRCA2, PALB2, TP53, CDH1, or PTEN.
Riceverò un nuovo trattamento in questo studio?
The study focuses on observing outcomes over time for women who have already had or are considering a nipple-sparing mastectomy, rather than providing a new treatment.
Come saperne di più
Stephanie Wong, MD
Parla sempre con il tuo medico di base o specialista prima di decidere di partecipare a uno studio.
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