About tretinoin capsules

Tretinoin is an anti-cancer medicine used to treat a type of leukaemia called acute promyelocytic leukaemia (APL or APML). This is a cancer where the bone marrow makes large numbers of immature white blood cells. White blood cells usually help the body to fight infection, but in leukaemia the development of these white blood cells goes wrong. The accumulation of the abnormal immature white blood cells in the bone marrow causes an overall reduction in the number of blood cells in the blood. This leads to many of the symptoms of APL, such as anaemia, infection and blood clotting and bleeding problems.

Tretinoin is a medicine which is related to vitamin A. It works by slowing the growth of the abnormal blood cells responsible for the cancer. It will be prescribed for you by a specialist doctor.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking tretinoin it is important that your doctor knows:

• Se sei incinta, stai cercando di avere un bambino o stai allattando.

• Se hai problemi con il funzionamento del tuo fegato, o se hai problemi con il funzionamento dei tuoi reni.

• If you have ever had depression, severe anxiety, or any other mental health problem.

• If you are taking any other medicines. This includes any medicines which are available to buy without a prescription, as well as herbal and complementary medicines. It is particularly important that your doctor should know if you are taking any antibiotics or vitamins.

• Se hai mai avuto una reazione allergica a un medicinale.

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about tretinoin, and will also provide you with a full list of the side-effects which you could experience from taking it.

• Tretinoin will be prescribed for you by a specialist doctor who is experienced in treating your condition. Your dose will be calculated from your weight and height, so it is important that you take the capsules exactly as your doctor tells you to. You will be asked to take two doses a day, and you will be told how many capsules to take for each dose. This information will also be printed on the label of the pack of capsules to remind you about what the doctor said to you.

• Swallow the capsules with a drink of water at a mealtime. Do not chew or open the capsules. Try to take the doses at the same times of day each day, as this will help you to remember to take tretinoin capsules regularly.

• If you forget to take a dose at your usual time, take it (with something to eat) when you remember. However, if it is nearly time to take your next dose when you remember then leave out the forgotten dose and take the next dose when it is due. Do not take two doses together to make up for a missed dose.

• A course of treatment can last up to three months.
  

• You must try to keep your regular appointments with your doctor or hospital. This is so your doctor can check on your progress. You will need to have regular blood tests and check-ups during your treatment.

• Tretinoin can be harmful to an unborn child, so women must avoid getting pregnant during the treatment and for at least a month afterwards. If this could affect you, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. Some oral contraceptives are not suitable with tretinoin so it is important that you ask your doctor for advice before you start the treatment.

• If you buy any medicines, check with a pharmacist that they are suitable to take with tretinoin. This includes any preparations which may contain vitamins, as you must not take vitamin A supplements while you are on tretinoin.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with tretinoin. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se si verificano altri sintomi che ritieni possano essere dovuti al medicinale, parla con il tuo medico o farmacista per ulteriori consigli.

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.