Rufinamide per l'epilessia

About rufinamide

Avere l'epilessia means that you have had more than one unexplained fit, or seizure. A seizure is a short episode of symptoms caused by a burst of abnormal electrical activity in your brain. Because different parts of the brain control different functions, your symptoms will depend on which part of your brain is affected. Symptoms that may occur during a seizure can affect your muscles, sensations, behaviour, emotions, and consciousness, or a combination of these.

Rufinamide is prescribed for a type of epilepsy known as Lennox-Gastaut syndrome. This is a severe form of epilepsy which usually begins in early childhood. Rufinamide works by stabilising the electrical activity of the brain, which reduces the number of seizures which occur. It is given alongside other antiepileptic medicines.

Before taking rufinamide

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you (or your child if you are their carer) start taking rufinamide, it is important that your doctor knows:

• Se hai problemi con il funzionamento del tuo fegato.

• Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.

• Se hai mai avuto una reazione allergica a un medicinale.

• Se sei incinta, stai cercando di avere un bambino o stai allattando.

How to take rufinamide

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about rufinamide and will provide you with a full list of the side-effects which you may experience from taking it.

• Take rufinamide exactly as your doctor tells you to. Your dose will be printed on the label of the pack to remind you about what the doctor said. There are several different strengths of rufinamide tablets. It is usual to start treatment on a low dose, and then for the dose to be increased gradually to a regular maintenance dose. You will be prescribed two doses a day: one dose to take in the morning and the other in the evening.

• It is important you try to take your doses at the same times of day - having a routine will help you to remember to take the doses regularly.

• You should take rufinamide with, or just after, a meal. Swallow the tablet with a drink of water. If you have difficulty swallowing tablets, you can crush the tablet and mix it into a small glassful of water.

• If you have been supplied with the oral liquid medicine (Inovelon® suspension), shake the bottle well before you measure out a dose. Instructions for using the dose syringe supplied with the suspension are below.

• Se dimentichi di prendere una dose, prendila appena te ne ricordi. Se quando te ne ricordi è quasi ora della dose successiva, prendi la dose successiva quando è il momento, ma salta la dose dimenticata. Non prendere due dosi insieme per compensare una dose dimenticata.

Instructions for using the Inovelon® suspension dosing syringe

1. Shake the bottle well.

2. Remove the bottle cap, and push the adaptor into the top of the open bottle.

3. Insert the syringe into the adapter.

4. Capovolgi la bottiglia (con la siringa collegata ad essa).

5. Gently pull out the plunger of the syringe so that the suspension fills the syringe to the mark which corresponds to your dose.

6. Rimettere la bottiglia nella posizione corretta e rimuovere la siringa dalla bottiglia.

7. Leave the adaptor in place, and replace the cap on the bottle.

8. Put the tip of the syringe into your (or your child's) mouth, and gently push the plunger so that the liquid is released into your (or your child's) mouth.

Ottenere il massimo da questo trattamento

• Quando inizi un nuovo trattamento per l'epilessia, potrebbe esserci un cambiamento nel numero o nel tipo di crisi che sperimenti. Il tuo medico ti consiglierà a riguardo.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your (or your child's) progress.

• Different formulations of some antiepileptic medicines can act in a slightly different way in your body. Because of this, your doctor may recommend that you continue to take the same form of rufinamide (that is, tablets or liquid medicine) from the same manufacturer each time you obtain a new supply. If so, each time you collect a prescription, check to make sure your supply looks the same and that the name is the same. If you are unsure, or if you have any questions about your prescription, please ask your pharmacist to advise you.

• Durante il trattamento per l'epilessia, c'è un piccolo rischio di sviluppare cambiamenti d'umore, pensieri angoscianti e sentimenti di suicidio. Se ciò accade, devi informare immediatamente il tuo medico.

• Le persone con epilessia devono smettere di guidare inizialmente. Il tuo medico ti consiglierà su quando potrebbe essere possibile ricominciare a guidare. Di solito sarà dopo un anno senza crisi epilettiche.

• Se bevi alcolici, chiedi consiglio al tuo medico. Il tuo medico potrebbe consigliarti di non bere alcolici mentre stai assumendo questo medicinale.

• Se acquisti dei medicinali, verifica con un farmacista che siano adatti da assumere insieme al tuo farmaco antiepilettico.

• Many antiepileptic medicines can harm an unborn child. If you are a woman, make sure you have discussed with your doctor which types of contraception are suitable for you and your partner. If you want to have a family, discuss this with your doctor so that you can be given advice from a specialist prima you become pregnant.

• You need to take rufinamide regularly every day. Do not stop taking it unless your doctor tells you to stop. Stopping treatment suddenly can cause problems and your doctor will want you to reduce your dose gradually if this becomes necessary.

Can rufinamide cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with rufinamide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Se si verificano altri sintomi che ritieni possano essere dovuti al medicinale, parla con il tuo medico o farmacista per ulteriori consigli.

How to store rufinamide

• Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

• Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.

Informazioni importanti su tutti i medicinali