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Quinapril tablets

Quinapril is generally well tolerated but if you develop a troublesome cough, you must let your doctor know.

The first dose in particular can make you feel dizzy. It is best taken just before you go to sleep.

Some painkillers and indigestion remedies could interfere with quinapril. Ask your pharmacist for advice before you buy any medicines 'over the counter'.

Clinical author's note: Michael Stewart 15/11/2018: Following an MHRA update, new advice has been added to this leaflet for people also taking the blood pressure medicine hydrochlorothiazide. Hydrochlorothiazide is only available in the UK in combination with other medicines used to treat high blood pressure. It may be available on its own in other countries. For more information see the warning below in 'can this medicine cause problems?' or view the Avviso MHRA.


At a glance

  • Quinapril is an ACE inhibitor used to treat high blood pressure and heart failure.

  • It works by widening blood vessels and helping to reduce excess fluid in the blood.

  • Take quinapril exactly as prescribed by your doctor, usually once daily.

  • The first dose may cause dizziness, so your doctor may advise taking it at bedtime.

  • Common side-effects include dizziness, a dry cough, and headache.

  • Stop taking quinapril and seek immediate medical help if you have difficulty breathing or swelling of your face, mouth, tongue, or throat.

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About quinapril

Tipo di medicinale

An angiotensin-converting enzyme (ACE) inhibitor

Utilizzato per

High blood pressure (hypertension); heart failure

Chiamato anche

Accupro® (discontinued); Accupril® (USA)
Combination brand: Accuretic® (quinapril with hydrochlorothiazide)

Disponibile come

Compresse

Quinapril belongs to a class of medicines called angiotensin-converting enzyme inhibitors, or ACE inhibitors. You may have been prescribed it to reduce pressione alta (ipertensione), or to treat insufficienza cardiaca. Your doctor will tell you why it has been prescribed for you.

ACE inhibitors like quinapril prevent your body from creating a hormone known as angiotensin II. They do this by blocking (inhibiting) a chemical called angiotensin-converting enzyme. They widen your blood vessels and help to reduce the amount of water put back into your blood by your kidneys.

These actions help to decrease blood pressure. Although people with high blood pressure often do not feel unwell, if left untreated, high blood pressure can harm the heart and damage blood vessels, leading to a heart attack or stroke.

Heart failure is a condition in which your heart does not work as well as it should. Because of this, there may be too much circulating fluid in your blood vessels. Quinapril helps to reduce this. It also appears to have a protective effect on the heart.

You may be prescribed quinapril on its own, or alongside other medicines to help your condition. The brand of quinapril called Accuretic® also contains a medicine called hydrochlorothiazide. This brand can be prescribed for people with high blood pressure. Combination brands like this help to reduce the total number of tablets you need to take each day.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking quinapril it is important that your doctor knows:

  • Se sei incinta o stai allattando.

  • If you have problems with the way your kidneys work, or any problems with the way your liver works.

  • If you are lacking in fluid in the body (dehydrated) - for example, if you have had diarrhoea or sickness very recently.

  • If you have been told you have a build-up of fatty deposits on the walls of your arteries, a condition called atherosclerosis.

  • If you have a particular type of poor circulation called peripheral arterial disease.

  • If you have collagen vascular disease. This includes conditions such as systemic lupus erythematosus (SLE) and scleroderma.

  • If you have been told you have a problem with the way your heart pumps blood

  • If you have been told you have heart muscle disease (cardiomyopathy), problems with the way your heart pumps blood, or narrowing of the main blood vessel from your heart (aortic stenosis).

  • If you have been told you have a low level of sodium in your blood.

  • If you have ever had a reaction where your face, tongue or throat swells (angio-oedema).

  • If you are having desensitisation treatment to protect against bee and wasp stings.

  • If you are having dialysis treatment, or treatment to remove cholesterol from your blood by a machine (LDL apheresis).

  • Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.

  • If you have ever had an allergic or unusual reaction to any other ACE inhibitor (such as lisinopril, ramipril or enalapril), or to any other medicine.

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  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about quinapril and will provide you with a full list of side-effects which you may experience from taking it.

  • Take the tablets exactly as your doctor tells you to. Quinapril is usually taken once daily, but it can also be prescribed as a twice-daily dose. Your dose will be printed on the label of the pack of tablets to remind you about what the doctor said to you.

  • Your doctor is likely to advise you to take your very first dose at bedtime. This is because the first dose can make you feel dizzy.

  • After the first dose, you can take quinapril at a time of day you find easy to remember, but try to take it at the same times of day each day. This will help you to remember to take your doses regularly. You can take quinapril tablets either with or without food. Swallow the tablet with a drink of water.

  • Se dimentichi di prendere una dose, prendila appena te ne ricordi (a meno che non sia quasi ora della dose successiva, in tal caso salta la dose dimenticata e prendi la dose successiva come di consueto). Non prendere due dosi insieme per compensare una dose dimenticata.

  • Try to keep your regular appointments with your doctor. This is so your progress can be monitored. Your doctor may want you to have some blood tests from time to time to check that your kidneys are working well.

  • Each time you collect a prescription, check to make sure the tablets look the same as you have had before. This is because there are several strengths of tablet. If you have any questions about your tablets, please ask your pharmacist for advice.

  • It is very important that you follow any dietary and lifestyle advice that you are given by your doctor. This may include advice about eating a healthy diet, not smoking, and taking regular exercise.

  • If you buy any medicines, check with a pharmacist that they are suitable to take with quinapril. This is because some medicines (such as anti-inflammatory painkillers and indigestion remedies) could interfere with your treatment.

  • It is likely that your doctor will advise that you do not use salt substitutes while you are taking quinapril. These products have a high content of potassium which could be harmful for you.

  • If you drink alcohol, ask your doctor for advice about drinking alcohol while you are on quinapril. Alcoholic drinks can make you feel light-headed or dizzy, and they may not be advisable for you.

  • If you are having an operation or dental treatment, tell the person carrying out the treatment that you are taking quinapril tablets. This is because some anaesthetics could cause your blood pressure to drop too low.

  • Treatment with quinapril is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise.

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Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with quinapril. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common quinapril side-effects (these affect fewer than 1 in 10 people)

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Feeling light-headed or dizzy, especially when standing up

Getting up more slowly should help. If you begin to feel

dizzy, lie down so that you do not faint, then sit for a few moments before standing. If this continues beyond the first few days, speak with your doctor. Do not drive and do not use tools or machines while you feel dizzy

Dry irritating cough

If this continues, speak with your doctor, as an alternative medicine may be better for you

Headache, other aches and pains

Chiedi al tuo farmacista di consigliare un antidolorifico adatto

Feeling sick (nausea) or being sick (vomiting), indigestion, tummy (abdominal) pain, diarrhoea

Stick to simple foods - avoid rich and spicy meals

Throat infections, runny nose, tingling feelings in your hands or toes, problems sleeping or feeling tired

Parla con il tuo medico se uno di questi diventa problematico

Importante: if you experience any of the following rare but serious symptoms, stop taking quinapril and contact your doctor for advice straightaway:

  • Any difficulty breathing, or swelling of your face, mouth, tongue or throat. These are signs of an allergic reaction.

  • Any yellowing of your skin or whites of your eyes. These may be signs of jaundice which is a rare side-effect.

  • A severe skin rash.

Se stai assumendo anche idroclorotiazide in combinazione con questo medicinale:

  • Studi hanno suggerito che assumere dosi più elevate di idroclorotiazide per lunghi periodi di tempo potrebbe aumentare il rischio di alcuni tipi di cancro della pelle.

  • Informa il tuo medico se sei mai stato trattato per il cancro della pelle in passato.

  • Informa il tuo medico di eventuali nei nuovi o modificati o segni preoccupanti sulla tua pelle.

  • Usa una crema solare sotto il sole forte. Non usare lettini abbronzanti.

Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, parla con il tuo medico o farmacista per ulteriori consigli.

  • Tenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.

  • Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.

Informazioni importanti su tutti i medicinali

Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.

Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.

Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.

Se hai domande su questo medicinale, chiedi al tuo farmacista.

Segnala effetti collaterali di un medicinale o vaccino

Se si verificano effetti collaterali, è possibile segnalarli online tramite il Yellow Card website.

verificatore di sintomi

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Controlla le possibili interazioni tra farmaci, integratori e alimenti prima di assumerli insieme.

Domande frequenti

Can I take quinapril if I am planning to become pregnant or breastfeed?

If you are pregnant, planning a pregnancy, or breastfeeding, it's important to inform your doctor. Quinapril may not be suitable in these circumstances, and your doctor will consider this as part of your overall care.

What should I do if I get diarrhoea or start feeling sick while taking quinapril?

If you experience diarrhoea or sickness (vomiting) very recently, you should inform your doctor. Being lacking in fluid in the body (dehydrated) is a factor your doctor needs to be aware of before or while you are taking quinapril.

Are there any specific medicines I should avoid taking with quinapril that I can buy without a prescription?

Yes, it's important to check with a pharmacist about any medicines you buy without a prescription, including herbal and complementary remedies, as some can interfere with quinapril. Specifically, some anti-inflammatory painkillers and indigestion remedies could affect your treatment. Additionally, avoid using salt substitutes as they have a high potassium content which could be harmful.

How long will I need to take quinapril?

Treatment with quinapril is usually long-term. You should continue to take the tablets unless your doctor advises you otherwise.

What should I do if I notice a dry cough after starting quinapril?

A dry, irritating cough is a common side-effect of quinapril. If it continues and becomes troublesome, you should speak with your doctor. They may consider if an alternative medicine would be better for you.

If I am taking Accuretic®, what precautions should I take regarding sun exposure?

If you are taking Accuretic®, which contains hydrochlorothiazide, you should use a sunscreen when in strong sunlight. It is also advised not to use sunbeds, as studies suggest that higher doses of hydrochlorothiazide for long periods might increase the risk of certain skin cancers. You should also tell your doctor about any new or changed moles or worrying marks on your skin, or if you have previously been treated for skin cancer.

Ulteriori letture e riferimenti

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About the authorView full bio

Author image

Michael Stewart, MRPharmS

Medicine Leaflet Review Manager – Contractor, Pharmacist

BPharm (Hons), MRPharmS

Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.

About the reviewer

Author image

Sid Dajani

Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.

Storia dell'articolo

Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.

  • Prossima revisione prevista: 15 Feb 2028
  • 15 Feb 2025 | Ultima versione

    Ultimo aggiornamento di

    Michael Stewart, MRPharmS

    Revisione paritaria di

    Sid Dajani
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