Norethisterone for painful or heavy periods
Primolut N, Utovlan
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 17 Feb 2023
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Norethisterone is a female hormone treatment.
The usual dose is one tablet either two or three times daily. You may be asked to take the tablets regularly each day, or just to take them on certain days of the month.
The most common side-effects are feeling bloated, feeling sick (nausea), and headache. These are generally mild in nature.
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About norethisterone
Tipo di medicinale | Progestogen (female hormone) |
Utilizzato per | Painful or heavy periods, particularly when associated with endometriosis |
Chiamato anche | Norethindrone (in US); Primolut N®, Utovlan® |
Disponibile come | Compresse |
Norethisterone is a man-made form of progesterone, a naturally occurring female sex hormone. It is referred to as a progestogen and it has a number of uses. Low doses are used to prevent pregnancy, or as hormone replacement therapy (HRT). Medium-strength tablets (5 mg) such as Primolut N® and Utovlan® are used to treat heavy and painful periods particularly if they are associated with a condition called endometriosi. Higher doses are used in the treatment of some female cancers, such as breast cancer.
This leaflet discusses norethisterone when it is used to treat painful or heavy periods associated with endometriosis. Endometriosis is a condition where tissue which is normally only found inside the womb (uterus), becomes 'trapped' in other parts of the body, often in the pelvic area or lower abdomen. This causes symptoms such as painful and heavy periods. Treatment aims to reduce the pain and amount of blood loss. Norethisterone can also be considered for heavy periods not associated with endometriosis, although other treatment options are more commonly prescribed for this.
There are a number of other medicine leaflets which will give you more information about norethisterone if you are taking it for contraception or as HRT. These are: Compresse contraccettive solo progestiniche, Norethisterone contraceptive injection, Combined hormonal contraceptives e Estrogeni e progestinici per la TOS.
Before taking norethisterone
Torna ai contenutiSome medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking norethisterone it is important that your doctor knows:
Se sei incinta o stai allattando.
If you have any problems with the way your liver works, or any kidney problems.
If you have heart or blood vessel problems, or if you have ever had a blood clot in an artery or vein.
If you have any of the following: diabetes, epilepsy, migraines, high blood pressure (hypertension), or asthma.
If you smoke, are overweight or have high cholesterol levels.
If you have ever had cancer.
If you have ever had a depressive illness.
If you have ever had yellowing of your skin or the whites of your eyes (jaundice), severe itching, or a skin condition called pemphigoid gestationis during a pregnancy.
Se hai un raro disturbo ereditario del sangue chiamato porfiria.
Se stai assumendo altri medicinali. Questo include qualsiasi medicinale che stai assumendo e che è disponibile per l'acquisto senza prescrizione medica, così come i medicinali a base di erbe e complementari.
Se hai mai avuto una reazione allergica a un medicinale.
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How to take norethisterone
Torna ai contenutiBefore you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about norethisterone and will provide you with a full list of the side-effects which you may experience from taking it.
Take norethisterone exactly as your doctor tells you to. You may be asked to take the tablets regularly each day, or to take them just on certain days of your monthly cycle. This information will be printed on the label of your pack of tablets to remind you, but if you are still unsure, ask your pharmacist for further advice.
It is common to take one tablet three times each day, although your dose may be different to this.
Swallow the tablets with a drink of water. You can take norethisterone tablets either before or after meals.
Try to take your doses at the same times of day, as this will help you to remember to take your doses.
If you do forget to take a dose at your usual time, take it as soon as you remember, unless it is nearly time for your next dose in which case leave out the forgotten dose. Remember to take your next dose when it is due but do not take two doses together to make up for a forgotten dose.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiCerca di mantenere i tuoi appuntamenti regolari con il tuo medico. Questo è per permettere al tuo medico di controllare i tuoi progressi.
You should avoid getting pregnant, as norethisterone can affect a developing baby. Use barrier methods of contraception (such as a condom) if you have sex whilst taking norethisterone. If you need further contraceptive advice, speak with your doctor.
If you have diabetes you may need to check your blood glucose more frequently, as norethisterone can affect the levels of sugar in your blood. Your doctor will be able to advise you about this.
If you are due to have an operation or any medical treatment, tell the person carrying out the treatment that you are taking norethisterone.
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Can norethisterone cause problems?
Torna ai contenutiAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with norethisterone. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common norethisterone side-effects | Cosa posso fare se sperimento questo? |
Shorter periods, no periods, breakthrough bleeding, 'spotting' | Your doctor will discuss this with you before you start treatment |
Sensazione di nausea | Stick to simple meals - avoid rich and spicy foods. If you are not already doing so, try taking the tablets after a meal |
Mal di testa | Ask your pharmacist to recommend a suitable painkiller. If the headache is unusually severe or continues, speak with your doctor straightaway |
Bloating, fluid retention | Se problematico, parla con il tuo medico |
Less common norethisterone side-effects | Cosa posso fare se sperimento questo? |
Feeling dizzy, breast tenderness, changes in weight, feeling tired or difficulty sleeping, feeling depressed, lack of interest in sex, skin reactions | Se uno di questi diventa problematico, parla con il tuo medico |
Importante: norethisterone can also have some serious side-effects, although these occur only rarely. If you experience any of the following symptoms, stop taking the tablets and contact your doctor for advice straightaway:
Any feeling of pain or tightness in your chest.
Any disturbances of your vision or hearing.
Any unusually severe headaches.
Qualsiasi ingiallimento della pelle o del bianco degli occhi (ittero).
Se si verificano altri sintomi che ritieni possano essere dovuti alle compresse, consulta il tuo medico o farmacista per un consiglio.
How to store norethisterone
Torna ai contenutiTenere tutti i medicinali fuori dalla portata e dalla vista dei bambini.
Conservare in un luogo fresco e asciutto, lontano da fonti di calore e luce diretta.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
Non assumere mai più della dose prescritta. Se sospetti che tu o qualcun altro possa aver assunto un sovradosaggio di questo medicinale, recati al pronto soccorso del tuo ospedale locale. Porta con te il contenitore, anche se è vuoto.
Questo medicinale è per te. Non darlo mai ad altre persone, anche se la loro condizione sembra essere la stessa della tua.
If you buy any medicines 'over the counter', always check with a pharmacist that they are suitable to take with your other medicines.
Non conservare medicinali scaduti o indesiderati. Portali alla tua farmacia locale che li smaltirà per te.
Se hai domande su questo medicinale, chiedi al tuo farmacista.
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Ulteriori letture e riferimenti
- Manufacturer's PIL, Utovlan® tablets; Pfizer Limited, The electronic Medicines Compendium. Dated December 2018.
- Manufacturer's PIL, Primolut N®; Bayer plc, The electronic Medicines Compendium. Dated July 2021.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
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Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Next review due: 16 Aug 2027
17 Feb 2023 | Ultima versione

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