Etonogestrel contraceptive implant
Nexplanon
Revisione paritaria di Sid DajaniUltimo aggiornamento di Michael Stewart, MRPharmSUltimo aggiornamento 9 maggio 2023
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The etonogestrel implant is used to prevent pregnancy.
Read the manufacturer's information leaflet from inside the pack before having the implant.
As with most hormonal contraceptives, side-effects include breast discomfort, fluid retention and an increase in acne.
At a glance
Etonogestrel is a long-acting contraceptive implant inserted under the skin of your upper arm.
It slowly releases a hormone to prevent pregnancy for up to three years.
The implant works by stopping egg release, changing the womb lining and thickening cervical mucus.
Irregular bleeding is a common side-effect, and periods may become infrequent or stop.
Inform your doctor about your implant if prescribed other medicines, as some can reduce its effectiveness.
Contact your doctor if you suspect pregnancy or notice changes to the implant or surrounding skin.
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About etonogestrel contraceptive implants
Tipo di medicinale | Progestogen |
Utilizzato per | Contraccezione |
Chiamato anche | Nexplanon® |
Disponibile come | Implant |
Etonogestrel is a progestogen, which is a female sex hormone similar to the progesterone hormone made naturally by your ovaries. An implant containing etonogestrel is a long-acting, effective and convenient form of contraccezione. The implant is a small flexible tube which is put under the surface of your skin on your upper arm. It releases etonogestrel slowly into your bloodstream. Each implant will provide contraception for up to three years. Nexplanon® is the brand name of the etonogestrel implant prescribed in the UK at present.
Etonogestrel works mainly by stopping ovulation (the release of an egg from the ovary). It also changes the lining of your womb (uterus) to make it less likely that an egg would attach to it, even if an egg were to fertilise. In addition, the mucus which forms a plug in your cervix becomes thicker. This stops sperm getting through to the uterus to fertilise an egg.
Before you have an etonogestrel implant
Torna ai contenutiSome medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before having Nexplanon® it is important that your doctor knows:
If you think you could already be pregnant.
Se hai problemi con il funzionamento del tuo fegato.
Se hai un problema con le tue arterie, chiamato malattia arteriosa.
Se hai una cisti ovarica o qualsiasi sanguinamento vaginale diverso dal tuo normale ciclo mensile.
If you have systemic lupus erythematosus, an inflammatory condition often called SLE.
If you have ever had an ectopic pregnancy or if you have developed severe itching or yellowing of your skin or the whites of your eyes (jaundice) during a pregnancy.
Se hai avuto un tumore al seno o un tumore che ti è stato detto dipende da un ormone sessuale.
Se hai un raro disturbo ereditario del sangue chiamato porfiria.
Se hai mai avuto una malattia depressiva.
Se hai mai avuto una reazione allergica a un medicinale.
If you are taking any other medicines, including those available to buy without a prescription, as well as herbal and complementary medicines. This is because some medicines interfere with the way progestogen contraceptives work.
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How an etonogestrel implant is inserted
Torna ai contenutiBefore you are given the implant you will be asked to read the printed information leaflet from the implant package. The manufacturer's leaflet will give you important information about the implant and will provide a full list of the side-effects which you may experience from it. If, as a result of reading the leaflet, you have any questions, please discuss them with your doctor/nurse before you have the implant.
The implant will be inserted for you by a person who has been specially trained. A check will be made to ensure it is inserted correctly. Once this is confirmed, it is effective straightaway.
The implant is usually first inserted within five days of a period starting, to ensure that you are not pregnant. It will be put in the inner side of your upper arm. You will be given an injection of local anaesthetic to numb your skin, and a special needle will be used to put the implant in place. The area around the implant may be bruised and sore for a few days, but the wound will soon heal just like any other small cut.
You will be given a User Card which contains some details for you to keep. This will note the date the implant was inserted and will give a suggested date for it to be removed/replaced.
Ottenere il massimo dal tuo trattamento
Torna ai contenutiThe release of progestogen from the implant will usually cause changes to the pattern of your periods. During the first few months, it is common to have irregular bleeding. This usually settles after the first year, but it may remain. Sometimes periods are heavier and longer than before, and sometimes periods become infrequent and light, or even stop altogether. One in five women with the implant have no bleeding.
If you do develop irregular bleeding, mention it to your doctor. Irregular bleeding can occasionally be due to another reason - for example, an infection, which may need to be treated.
You may gain a little weight. Eating a well-balanced diet and taking regular exercise can help minimise this, but if it is a concern to you, discuss it with your doctor.
It is important to check your breasts regularly for any lumps or bumps. Speak with your doctor if you notice any changes.
If at any time you suspect that you may be pregnant, make an appointment to see your doctor as soon as possible. You should also make an appointment to see your doctor if you notice any changes to the feel of the implant, or to the look of the skin around where the implant was inserted.
Some medicines can reduce the effectiveness of this contraceptive. These include medicines for epilepsy, medicines to treat fungal infections, the herbal preparation St John's wort, and medicines used to treat tuberculosis (TB). Tell the doctor that you have a progestogen implant if you are prescribed any other medicines. If you buy any medicines 'over the counter', ask the pharmacist for advice.
Please note: the implant will not protect you against HIV (AIDS) or any other sexually transmitted infections.
The implant can be taken out at any time if you request removal. It loses its effect immediately after being removed. If you do not want to become pregnant, you must use another form of contraception straightaway afterwards.
A replacement implant is needed every three years if you wish to continue with this form of contraception. It requires a small procedure under local anaesthetic to remove the old implant and put in a new one.
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Can an etonogestrel implant cause problems?
Torna ai contenutiAlong with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with etonogestrel implants. You will find a full list in the manufacturer's information leaflet that has been given to you. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Very common Nexplanon® side-effects (these affect more than 1 in 10 women) | Cosa posso fare se sperimento questo? |
Mal di testa | Bevi molta acqua e chiedi al farmacista di consigliare un antidolorifico adatto. Se i mal di testa persistono, informa il tuo medico |
Vaginal infections, acne, increased weight, breast tenderness, irregular periods | Se sei preoccupato per uno di questi, parla con il tuo medico |
Common Nexplanon® side-effects (these affect fewer than 1 in 10 women) | Cosa posso fare se sperimento questo? |
Feeling sick (nausea), wind (flatulence), tummy (abdominal) pain | This does not usually last for long, but in the meantime, stick to simple meals |
Pain near the implant | This should pass as the wound heals |
Change in appetite, lack of interest in sex, mood changes, hot flushes, feeling dizzy or tired, hair thinning, painful periods, flu-like symptoms | Se problematico, parla con il tuo medico |
If you experience any other symptoms which you think may be due to the implant, speak with your doctor or pharmacist for advice.
Informazioni importanti su tutti i medicinali
Torna ai contenutiInformazioni importanti su tutti i medicinali
If you are having an operation or any dental treatment, tell the person carrying out the treatment about all the medicines you are using.
If you have any questions about your medicines, ask your pharmacist.
Segnala effetti collaterali di un medicinale o vaccino
Se si verificano effetti collaterali, è possibile segnalarli online tramite il Yellow Card website.

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Domande frequenti
How soon after insertion is the etonogestrel implant an effective contraceptive?
The implant starts working immediately after it has been correctly inserted. This is typically done within five days of your period starting to ensure you are not pregnant at the time of insertion.
I'm concerned about irregular bleeding; should I always contact my doctor?
Yes, it is important to mention any irregular bleeding to your doctor. While changes to your period pattern are common with the implant, irregular bleeding can sometimes indicate another issue, such as an infection, which might require treatment.
Can the etonogestrel implant protect me from sexually transmitted infections (STIs)?
No, the etonogestrel implant is a contraceptive and will not protect you against HIV (AIDS) or any other sexually transmitted infections.
What happens if I decide I want to stop using the implant before the three years are up?
The implant can be removed at any time if you request it. Once removed, its contraceptive effect stops immediately. If you wish to avoid pregnancy, you must start using another form of contraception straight away after removal.
Will I need another procedure once my three years with the implant are finished?
Yes, if you wish to continue using this method of contraception, a replacement implant is required every three years. This involves a small procedure under local anaesthetic to remove the old implant and insert a new one.
What should I do if I notice any changes to the implant site on my arm?
You should make an appointment to see your doctor as soon as possible if you notice any changes to the feel of the implant, or to the appearance of the skin around where the implant was inserted.
Ulteriori letture e riferimenti
- Manufacturer's PIL, Nexplanon® 68 mg implant for subdermal use; Organon Pharma (UK) Ltd, Il compendio elettronico dei medicinali. Datato aprile 2022.
- Medicinali Completi BNF 89ª Edizione; Associazione Medica Britannica e Società Farmaceutica Reale di Gran Bretagna, Londra.
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About the authorView full bio

Michael Stewart, MRPharmS
Medicine Leaflet Review Manager – Contractor, Pharmacist
BPharm (Hons), MRPharmS
Michael is a community pharmacist practicing in the Midlands and South Yorkshire with more than 20 years’ experience advising on medicines and medical conditions. He has a strong background in healthcare training, having produced and delivered training courses for pharmacy teams and staff of residential care settings, including nurses. He has also contributed to pharmacy advisory boards for the management of low acuity conditions in the community.
About the reviewer

Sid Dajani
Sultan Dajani qualified at the London School of Pharmacy in 1994 and became the youngest elected member of the Royal Pharmaceutical Society council since its founding in 1842.
Storia dell'articolo
Le informazioni su questa pagina sono scritte e revisionate da clinici qualificati.
Prossima revisione prevista: 4 Nov 2027
9 maggio 2023 | Ultima versione

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