Can I take Qutan and Valparin chrono together?
Drug interaction guide
Originally published 12 May 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can increase the risk of side effects, particularly extreme drowsiness, dizziness, and confusion. There is also a risk of changes to your liver function or blood cell counts. In some cases, Valparin Chrono (sodium valproate) can change the levels of Qutan (quetiapine) in your blood, making it less effective or more toxic.
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Why this happens
Both medicines affect the central nervous system, leading to an 'additive' effect where the sedative properties of both are strengthened. Additionally, Valparin Chrono can interfere with the liver enzymes that break down Qutan, potentially altering its concentration in the body.
What you should do
Back to contentsYou must speak to your doctor before taking these together. They may need to perform regular blood tests to check your liver function and blood cell counts. Do not drive or operate machinery until you know how this combination affects you. Seek medical advice if you notice yellowing of the skin or eyes, unusual bruising, or extreme tiredness.
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Important precautions
Back to contentsPregnancy
This medicine will seriously harm an unborn baby. It must not be used by girls or women of childbearing age unless a specialist Pregnancy Prevention Programme (PPP) is in place. You must use highly effective contraception and have regular pregnancy tests.
Suicidal thoughts and behaviour
These medicines can increase the risk of suicidal thoughts or self-harm, particularly when first starting treatment. You or your carers must monitor for any sudden changes in mood or behaviour and seek medical help immediately if they occur.
Liver or Pancreas disorders
Seek urgent medical attention if you develop severe stomach pain, yellowing of the skin or eyes, or unexplained vomiting, as these can be signs of life-threatening liver failure or pancreatitis.
Food and drink warnings
Back to contentsAlcohol
Drinking alcohol while taking this medicine can make you feel very sleepy and dizzy. It is best to avoid alcohol, especially when you first start treatment or if your dose is increased.
Grapefruit juice
You should avoid drinking grapefruit juice. It can increase the amount of quetiapine in your blood, which makes side effects more likely.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
12 May 2026 | Originally published
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