Can I take Omeprazole and Vitamin d3 together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
There is no significant interaction between omeprazole and vitamin D3. It is generally safe to take these two together.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Omeprazole reduces stomach acid, which can sometimes affect how certain minerals (like calcium) are absorbed. However, vitamin D3 is fat-soluble and does not require a highly acidic environment for the body to process it effectively.
What you should do
Back to contentsYou can continue taking both as prescribed. For the best absorption of vitamin D3, it is often recommended to take it with a meal that contains a little bit of fat (like yoghurt, eggs, or avocado).
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Folitrax and Hqtor together?
Taking Folitrax (methotrexate) and Hqtor (hydroxychloroquine) together can increase the risk of side effects, particularly those affecting the liver. However, these two medicines are very commonly prescribed together by specialists to treat conditions like rheumatoid arthritis. While they work well as a team to control inflammation, they require careful monitoring.

Treatment and medication
Can I take Acetaminophen and Levocetirizine together?
Taking paracetamol (acetaminophen) and levocetirizine together is generally considered safe. There are no known major interactions between these two medicines. However, both can occasionally cause drowsiness or tiredness in some people. If you experience these side effects, they may be slightly more noticeable when taking both medicines at the same time.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.