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Can I take .metropolol and .aspirin together?

Drug interaction guide

Taking aspirin and metoprolol together may slightly reduce the blood pressure-lowering effect of metoprolol. Additionally, both medications can be tough on the stomach, potentially increasing the risk of irritation.

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Why this happens

Aspirin belongs to a group of medicines called NSAIDs. These can interfere with chemicals in the body called prostaglandins, which help keep blood vessels relaxed. By reducing these chemicals, aspirin can cause the body to retain a bit more salt and water, which slightly pushes blood pressure up, working against the metoprolol.

For most people, these two are prescribed together safely (especially after a heart attack). However, you should monitor your blood pressure regularly. If you notice your blood pressure readings are consistently higher than usual, or if you develop stomach pain or indigestion, speak to your doctor or pharmacist.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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