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Can I take Losec and Nicorandil together?

Drug interaction guide

Taking Losec (omeprazole) and nicorandil together may increase the risk of developing serious ulcers or sores in the digestive tract, particularly in the stomach or bowel. While Losec is often used to protect the stomach, there have been reports of unusual ulceration when used alongside nicorandil.

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Why this happens

Nicorandil is known to occasionally cause 'nicorandil-induced ulceration' in various parts of the body. The exact reason why taking a proton pump inhibitor (PPI) like Losec might complicate this is not fully understood, but it may involve changes in the protective lining of the gut or a delay in recognising the symptoms of an ulcer.

You can take these medicines together, but you must be vigilant. Contact your doctor immediately if you notice any new or worsening abdominal pain, blood in your stools (which may look black or tarry), or if you vomit blood. Your doctor will monitor you for any signs of gastrointestinal damage.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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