Can I take Levothyroxine and Ramipril together?
Drug interaction guide
Originally published 14 Mar 2026
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There is no direct interaction between levothyroxine and ramipril. However, if your thyroid levels are not well-controlled, it can affect how well your blood pressure medication works.
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Why this happens
Levothyroxine replaces thyroid hormone, while ramipril is an ACE inhibitor used for blood pressure. They do not interfere with each other's absorption or metabolism. However, thyroid hormones naturally influence heart rate and blood pressure. If your thyroid becomes overactive or underactive, your blood pressure may change, requiring an adjustment to your ramipril dose.
What you should do
Back to contentsYou can safely take these medicines together. It is usually best to take levothyroxine on an empty stomach, at least 30 to 60 minutes before breakfast. Ramipril can be taken with or without food. Ensure you have regular blood tests to monitor your thyroid levels and blood pressure as requested by your doctor.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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