Can I take Lenzetto spray and Microgram together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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There is no known interaction between Microgynon (the likely intended medication) and Lenzetto spray. However, using both together is unusual because they both contain oestrogen. This could lead to an 'oestrogen overdose', causing symptoms like breast tenderness, nausea, or unexpected vaginal bleeding.
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Why this happens
Both medications contain oestrogen. Microgynon is a combined oral contraceptive pill (containing ethinylestradiol and levonorgestrel), while Lenzetto is a Hormone Replacement Therapy (HRT) spray (containing estradiol). Taking both increases the total amount of oestrogen in your body beyond the recommended dose for either condition.
What you should do
Back to contentsYou should not use both Microgynon and Lenzetto at the same time unless specifically instructed by a specialist. They are generally used for different purposes (contraception vs. menopause symptoms) and using both can cause hormonal imbalances. Speak to your GP or pharmacist to ensure you are on the correct single treatment for your needs.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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