Can I take Fluvoxamine and Olanzapine together?

Why this happens

Your liver uses a specific protein (enzyme) called CYP1A2 to break down olanzapine and remove it from your body. Fluvoxamine is a very strong 'inhibitor' of this protein, meaning it blocks the liver's ability to clear the olanzapine. This causes the olanzapine to build up to potentially toxic levels.

You must speak to your doctor before taking these two medicines together. If they are prescribed together, your doctor will usually need to prescribe a much lower dose of olanzapine than normal (often one-third of the usual dose). If you are already taking both and feel excessively drowsy, dizzy, or faint, contact your healthcare provider immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.