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Can I take Dextroamphetamine and Intuniv together?

Drug interaction guide

Taking these two medicines together can cause changes in your blood pressure and heart rate. While they are often prescribed together for ADHD, they have opposite effects on the cardiovascular system: dextroamphetamine is a stimulant that can raise blood pressure, while Intuniv (guanfacine) is a non-stimulant that typically lowers it. This combination can also increase the risk of feeling very sleepy or dizzy.

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Why this happens

Dextroamphetamine increases the release of chemicals like norepinephrine which stimulate the heart and blood vessels. Intuniv works by stimulating specific receptors (alpha-2A) in the brain that tell the body to lower blood pressure and heart rate. When used together, they can cause unpredictable fluctuations in blood pressure or excessive slowing of the heart rate (bradycardia). Additionally, both can affect the central nervous system, potentially increasing drowsiness.

This combination is common in specialist ADHD treatment, but you must be monitored closely by your doctor. Have your blood pressure and heart rate checked regularly, especially when starting or changing doses. Seek medical advice if you feel very dizzy, faint, or notice a very slow or racing heartbeat. Do not stop taking Intuniv suddenly, as this can cause a dangerous spike in blood pressure.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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