Can I take Codeine paracetamol and Metformin together?
Drug interaction guide
Originally published 14 Mar 2026
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There is no direct interaction between paracetamol and metformin. However, codeine can occasionally cause a slight increase in blood sugar levels or mask the symptoms of low blood sugar (hypoglycaemia). Additionally, codeine can slow down the digestive system, which might slightly change how quickly metformin is absorbed, though this is rarely a clinical concern.
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Why this happens
Codeine is an opioid which slows down the movement of the gut (gastric emptying). This can delay the absorption of other oral medications like metformin. Opioids can also occasionally interfere with glucose metabolism.
What you should do
Back to contentsIt is generally safe to take these medicines together. However, if you have diabetes, you should monitor your blood sugar levels more closely when starting or increasing the dose of codeine. Be aware that codeine can cause constipation; ensure you drink plenty of water. If you feel unusually drowsy or dizzy, contact your doctor.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
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