Can I take Co-codamol and Pregabalin together?

Why this happens

Both medicines act as central nervous system (CNS) depressants. Co-codamol contains codeine (an opioid), and pregabalin is a nerve pain medicine. When used together, they have an 'additive effect', meaning they double up on their side effects, particularly those that slow down the brain and the muscles that control breathing.

You should only take these two medicines together if your doctor is aware and has specifically prescribed both. If you are taking them together, start with the lowest possible dose. Avoid driving or operating machinery until you know how the combination affects you. Seek urgent medical help if you experience extreme sleepiness, shallow breathing, or difficulty waking up.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.