Can I take Bisoprolol and Sertraline together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
Taking bisoprolol and sertraline together may occasionally cause your heart rate to slow down more than intended or lead to a slight drop in blood pressure when you stand up. While most people tolerate this combination well, it can sometimes lead to feeling dizzy, lightheaded, or unusually tired.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Bisoprolol is a beta-blocker that slows the heart rate. Sertraline can sometimes interfere with the liver enzymes (specifically CYP2D6) that help clear bisoprolol from your body. This can lead to slightly higher levels of bisoprolol in your blood, increasing its effect on your heart rate and blood pressure.
What you should do
Back to contentsYou can usually take these medicines together, but you should monitor how you feel. If you experience dizziness, fainting, or a very slow pulse, speak to your GP. Do not stop taking either medication without medical advice. It is helpful to stand up slowly from a sitting or lying position to prevent lightheadedness.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take 15 and Pregabalin together?
Combining alcohol with pregabalin can significantly increase the side effects of both substances. You may feel extremely drowsy, dizzy, or confused. It can also lead to problems with coordination, making you more likely to fall or have an accident. In more serious cases, it can slow down your breathing or make you lose consciousness.

Treatment and medication
Can I take Codeine and Magnesium together?
Taking magnesium and codeine together can lead to increased drowsiness and may cause constipation. Magnesium can also slightly interfere with how your body absorbs codeine if taken at the exact same time.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.