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Can I take Bisoprolol and Indapamide together?

Drug interaction guide

Taking bisoprolol and indapamide together can cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. There is also a small risk that the combination could affect the balance of minerals (electrolytes) in your blood.

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Why this happens

Both medicines work to lower blood pressure but in different ways: bisoprolol is a beta-blocker that slows the heart rate, while indapamide is a diuretic (water tablet) that helps the kidneys remove excess salt and water. When used together, their effects add up (an additive effect).

It is common for doctors to prescribe these together, but you should monitor your blood pressure regularly at home. To avoid dizziness, try to get up slowly from a sitting or lying position. If you feel very dizzy, have a racing heart, or feel unusually tired, contact your doctor. Ensure you attend any scheduled blood tests to check your kidney function and mineral levels.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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