Can I take Bisoprolol and Entresto together?

Why this happens

Both medicines work to lower blood pressure and protect the heart, but they do so in different ways. Bisoprolol is a beta-blocker that slows the heart rate, while Entresto (sacubitril/valsartan) relaxes blood vessels and removes excess fluid. When used together, their effects on blood pressure are added together (additive effect). Both can also affect how your kidneys manage potassium.

These two medicines are often prescribed together for heart failure, but they must be monitored closely by your doctor. When starting this combination or changing doses, move slowly when standing up to avoid dizziness. Your doctor will need to perform regular blood tests to check your kidney function and potassium levels. If you feel severely dizzy, faint, or notice a very slow heartbeat, contact your healthcare provider.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.