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Can I take . b aspirin and Hydrochloride together?

Drug interaction guide

Taking aspirin and sertraline together increases your risk of bleeding, particularly in your stomach or gut. You may bruise more easily or notice that small cuts take longer to stop bleeding. In more serious cases, it can lead to internal bleeding, which might show up as very dark or 'tar-like' stools, or vomiting blood.

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Why this happens

Both medicines affect how your blood clots. Aspirin prevents blood cells called platelets from sticking together. Sertraline, while primarily for mood, also reduces the amount of serotonin available in your platelets, which they need to help form clots. When used together, your blood becomes much thinner than usual.

You should speak to your doctor before taking these together. If your doctor has prescribed both, they have likely decided the benefit outweighs the risk, but you must be vigilant. Seek medical help immediately if you notice signs of internal bleeding, such as black/tarry stools, coughing up blood, or severe stomach pain. It is also best to avoid or strictly limit alcohol, as this can further irritate the stomach lining and increase bleeding risks.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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