Can I take Atorvastatin and Magnesium together?

Why this happens

Magnesium (specifically in antacid form) can bind to atorvastatin in the digestive tract or change the acidity of the stomach, which reduces the amount of the drug that enters your bloodstream.

You do not need to stop taking either, but you should space them out. Take your atorvastatin at least 2 hours before or 2 hours after taking any magnesium-containing antacids or supplements.

Pregnancy

You must not take atorvastatin if you are pregnant or trying to conceive, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle pain or weakness

You must report any unexplained muscle pain, tenderness, or weakness to your doctor immediately. In rare cases, this can lead to serious kidney problems.

Kidney disease

If you have severe kidney problems, you must consult your doctor before taking magnesium supplements, as your body may not be able to clear excess magnesium, leading to toxic levels.

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This can increase your risk of side effects, such as muscle pain or damage. Avoid drinking large quantities (more than 1.2 litres daily), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

Drinking large amounts of alcohol while taking atorvastatin can increase the risk of liver problems. It is advised to keep your alcohol intake within the recommended limits (no more than 14 units per week).

Large meals or high-fibre foods

Taking magnesium on an empty stomach can sometimes cause diarrhoea or stomach upset. However, very high-fibre meals may slightly reduce how much magnesium your body absorbs. It is generally best to take magnesium with a meal to reduce stomach irritation.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.