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Can I take Aspirin and Microgram together?

Drug interaction guide

Taking aspirin and misoprostol (the active ingredient in Cytotec, often measured in micrograms) together can increase the risk of irritation to your stomach lining and may cause digestive upset. However, in some medical cases, doctors actually prescribe them together because misoprostol can help protect the stomach from the damage aspirin might cause.

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Why this happens

Aspirin is an NSAID that can irritate the stomach lining. Misoprostol is a synthetic prostaglandin that protects the stomach but can also cause side effects like stomach cramps and diarrhoea. When used together, the digestive side effects of both may be more noticeable.

If your doctor has prescribed both, follow their instructions carefully as the misoprostol may be intended to protect your stomach. If you are taking aspirin for pain relief and notice stomach pain, indigestion, or severe diarrhoea while taking misoprostol, speak to your pharmacist or GP. Avoid taking extra aspirin if you are already using misoprostol for a stomach condition unless advised by a professional.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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