Can I take Aspirin and Doxycycline together?

Why this happens

Aspirin and doxycycline are processed by the body using different pathways. Aspirin works on enzymes that control pain and inflammation, while doxycycline is an antibiotic that stops bacteria from growing. They do not interfere with how each other is absorbed, broken down, or removed from the body.

You can take these medicines together as prescribed. However, doxycycline can sometimes cause an upset stomach or irritation to the food pipe (oesophagus). To prevent this, swallow the doxycycline tablet with a full glass of water while sitting or standing upright, and do not lie down for at least 30 minutes afterwards. If you have a history of stomach ulcers, speak to your pharmacist or doctor before taking aspirin regularly.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.