Can I take Antihistamines and Bisoprolol together?

Why this happens

Bisoprolol is a beta-blocker that slows the heart rate and lowers blood pressure. Some antihistamines (particularly older 'sedating' ones like diphenhydramine) have 'anticholinergic' effects that can oppose the heart-slowing effects of bisoprolol. Conversely, both types of medicine can cause drowsiness and low blood pressure, leading to an additive effect where you feel much more tired or dizzy than usual.

It is generally safe to take most modern, non-drowsy antihistamines (like cetirizine or loratadine) with bisoprolol. However, you should avoid older, sedating antihistamines (like diphenhydramine or chlorphenamine) unless specifically advised by your doctor. If you feel dizzy, lightheaded, or notice your pulse is unusually slow, speak to your pharmacist or GP.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.