Can I take Amlong and Zeptol cr together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together can cause the level of amlodipine (Amlong) in your blood to drop significantly. This means your blood pressure medication may stop working effectively, potentially leading to high blood pressure (hypertension) or chest pain (angina).
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Why this happens
Carbamazepine (Zeptol CR) is a powerful 'enzyme inducer'. It speeds up the liver's ability to break down other drugs. Because the liver processes amlodipine much faster than usual, the medicine is cleared from your body before it can do its job.
What you should do
Back to contentsYou should speak to your doctor before taking these together. Your doctor may need to increase your dose of Amlong or monitor your blood pressure more frequently. Do not stop taking either medication without medical advice.
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Important precautions
Back to contentsPregnancy
This medicine can cause serious birth defects and developmental problems. You must use effective contraception and speak to your doctor immediately if you plan to become pregnant or find out you are pregnant.
Severe Skin Reactions
Seek urgent medical help if you develop a skin rash, mouth sores, or blistering. This can be a sign of a rare but life-threatening skin reaction, particularly in people of Han Chinese or South-East Asian descent.
Grapefruit Juice Consumption
Do not drink grapefruit juice or eat grapefruit while taking this medicine, as it significantly increases the level of the drug in your blood and the risk of serious side effects.
Food and drink warnings
Back to contentsGrapefruit and Grapefruit Juice
Grapefruit can increase the amount of amlodipine in your blood, which may cause your blood pressure to drop too low and increase the risk of side effects like headaches or swelling. It is best to avoid grapefruit while taking this medicine.
Alcohol
Drinking alcohol while taking carbamazepine can make you feel very drowsy or dizzy. It can also increase the risk of side effects and may trigger seizures in some patients. It is best to avoid alcohol entirely.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking sertraline and trazodone together increases the risk of a rare but serious condition called serotonin syndrome. This happens when there is too much of a chemical called serotonin in your brain. You may also feel more drowsy, dizzy, or have difficulty concentrating.

Treatment and medication
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published

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