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Can I take Amlodipine besilate and Msm together?

Drug interaction guide

There is no evidence of a direct interaction between amlodipine and MSM. However, MSM may have a very mild blood-thinning effect or slightly lower blood pressure in some people. When taken with amlodipine, this could theoretically lead to blood pressure dropping slightly lower than intended, though this is not common.

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Why this happens

Amlodipine works by relaxing blood vessels to lower blood pressure. MSM (Methylsulfonylmethane) is a supplement often used for joint pain; while its effects on blood pressure are not well-studied in humans, some animal studies suggest it may have mild anti-inflammatory and vasodilatory (vessel-widening) properties that could overlap with amlodipine.

It is generally considered safe to take these together. However, as with any new supplement, you should monitor your blood pressure at home for the first week. If you feel dizzy, lightheaded, or unusually tired, speak to your GP or pharmacist. Always inform your doctor about all supplements you are taking.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 14 Mar 2026 | Originally published
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