Can I take Amlodipine and Ezetimibe together?
Drug interaction guide
Originally published 14 Mar 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
There is no known harmful interaction between amlodipine and ezetimibe. These two medicines work in different ways to help your heart and blood vessels. Amlodipine helps to lower blood pressure, while ezetimibe lowers cholesterol. Taking them together is common and generally considered safe.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Amlodipine is a calcium channel blocker that relaxes blood vessels, and ezetimibe works in the digestive tract to reduce cholesterol absorption. They do not interfere with each other's metabolism or absorption in the body.
What you should do
Back to contentsYou can continue taking both medicines as prescribed by your doctor. It is usually best to take them at the same time each day to help you remember. If you experience any new or unusual side effects, such as muscle pain or swelling in your ankles, mention this to your doctor or pharmacist at your next appointment.
Continue reading below
Important precautions
Back to contentsGrapefruit juice consumption
Avoid drinking large amounts of grapefruit juice. It can increase the level of amlodipine in your blood, making your blood pressure drop too low and increasing the risk of side effects.
Food and drink warnings
Back to contentsGrapefruit juice
Grapefruit juice can increase the amount of amlodipine in your blood. This may cause your blood pressure to drop too low or increase the risk of side effects like headaches, flushing, or swollen ankles. While small amounts are usually fine, it is best to avoid drinking large quantities of grapefruit juice.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Alodipine and Bisoprolol together?
Taking amlodipine and bisoprolol together can cause your blood pressure to drop lower than if you took either medicine alone. It can also significantly slow down your heart rate. This may make you feel dizzy, lightheaded, faint, or unusually tired.
Treatment and medication
Can I take Ashwagandha and Vitamin d2 together?
There are no known significant interactions between ashwagandha and vitamin D2 (ergocalciferol). It is generally considered safe to take these two supplements together.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
14 Mar 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.