Can I take Amitriptyline and Zopliclone together?

Why this happens

Both medicines work by slowing down the activity in your brain and central nervous system. Amitriptyline is a tricyclic antidepressant with sedative properties, and zopiclone is a 'Z-drug' used for sleep. When used together, their sedative effects add up (a 'synergistic' effect), making the overall impact much stronger than taking either medicine alone.

You should only take these two medicines together if your doctor is specifically aware you are using both and has told you to do so. If you are prescribed both, take them exactly as directed, usually right before bed. Do not drive, operate machinery, or drink alcohol while taking this combination. If you feel excessively sleepy the next day or have trouble breathing, contact your doctor immediately.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.