Can I take Amitriptyline and Venelafaxin together?

Why this happens

Both medicines increase the levels of a chemical called serotonin in the brain. When used together, serotonin levels can become dangerously high. Additionally, venlafaxine can slow down the way the liver processes amitriptyline, leading to higher levels of amitriptyline in your bloodstream.

You should only take these two medicines together if specifically prescribed and closely monitored by a specialist. If you are taking both and experience symptoms such as confusion, shivering, sweating, muscle twitching, or a very high fever, seek medical help immediately. Do not stop taking either medication without talking to your doctor first.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.